{"created":"2023-07-27T06:51:48.164843+00:00","id":45369,"links":{},"metadata":{"_buckets":{"deposit":"a39844f9-02ac-4a85-89fd-9da41e2676c8"},"_deposit":{"created_by":18,"id":"45369","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45369"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045369","sets":["2812:2813:2822"]},"author_link":["78875","248"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-18","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2009-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"思春期に内在性カンナビノイド受容体アゴニストを慢性投与したマウスの大脳皮質では統合失調症に特徴的なGABA伝達関連遺伝子の発現変化は認められなかった。一方、大脳皮質パルブアルブミン陽性介在ニューロンに特異的なカリウムチャンネルサブユニット遺伝子KCNS3の発現は、若年期にマリワナの主成分tetrahydrocannabinolの慢性投与を受けたサル及び統合失調症患者の大脳皮質において有意に低下していた。","subitem_description_type":"Abstract"},{"subitem_description":"In the neocortex of juvenile mice that received chronic injections of a endocannabinoid receptor agonist, we failed to replicate expression changes of certain GABA-related genes that were observed in schizophrenia. However, juvenile monkeys chronically exposed to tetrahydrocannabinol, the main psychoactive constituent of marijuana, expression levels of KCNS3, which encodes PV neuron-specific potassium channel subunit Kv9. 3, were significantly decreased in the prefrontal cortex(PFC). KCNS3 mRNA levels were also decreased in the PFC of subjects with schizophrenia.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「統合失調症の病態生理におけるカンナビノイドの重要性についての研究」課題番号21390332\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21390332/21390332seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051706","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40249959"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40249959","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390332/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390332/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21390332/21390332seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21390332/21390332seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-20"}],"displaytype":"detail","filename":"ME-PR-HASHIMOTO-T-kaken 2012-6p.pdf","filesize":[{"value":"329.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-HASHIMOTO-T-kaken 2012-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45369/files/ME-PR-HASHIMOTO-T-kaken 2012-6p.pdf"},"version_id":"c62ff5d9-3d33-4f37-9d5e-a43e4dc9ae2c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"統合失調症の病態生理におけるカンナビノイドの重要性についての研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"統合失調症の病態生理におけるカンナビノイドの重要性についての研究"},{"subitem_title":"Molecular mechanism of altered cannabinoid signaling in the pathophysiology schizophrenia","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-20"},"publish_date":"2018-07-20","publish_status":"0","recid":"45369","relation_version_is_last":true,"title":["統合失調症の病態生理におけるカンナビノイドの重要性についての研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:27:33.299849+00:00"}