{"created":"2023-07-27T06:51:48.253661+00:00","id":45371,"links":{},"metadata":{"_buckets":{"deposit":"83511de1-ca33-42f0-80b9-a1bf0cc1ec9b"},"_deposit":{"created_by":18,"id":"45371","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45371"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045371","sets":["2812:2813:2818"]},"author_link":["78882","78883"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05-25","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2013-04-01 - 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"中枢神経系細胞に発現する膜輸送体OCTN1の生理学的役割を解明する目的で、OCTN1による神経細胞の機能制御メカニズムおよびそのうつ病治療への応用の可能性について検討した。その結果、OCTN1による水溶性アミノ酸ergothioneineの取り込みは、mTORの活性化を介して神経栄養因子を誘導し、神経細胞への分化を促進することが示された。また、同作用を介して海馬歯状回における神経新生を促進することにより、抗うつ効果を発揮する可能性がある。さらに、OCTN1が抗うつ薬の効果に影響を及ぼす可能性も示された。","subitem_description_type":"Abstract"},{"subitem_description":"To clarify the physiological role of solute carrier OCTN1 expressed in the central nervous system, we examined neural control mechanisms by OCTN1 and the possible application to treatment of depression. The obtained results suggest that OCTN1-mediated ergothioneine uptake may promote neuronal differentiation via activation of mTOR and induction of neurotrophic factors, orally ingested ergothioneine may promote neurogenesis in the hippocampal dentate gyrus and alleviate symptoms of depression via the effects, and OCTN1 may modulate the pharmacological effects of antidepressants.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25460092, 研究期間(年度):2013-04-01 - 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「膜輸送体OCTN1による神経細胞の機能制御機構とうつ病治療への応用に関する研究」課題番号25460092\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25460092/25460092seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051708","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10401895"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10401895","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25460092/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25460092/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25460092/25460092seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25460092/25460092seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-20"}],"displaytype":"detail","filename":"PH-PR-NAKAMICHI-N-kaken 2016-6p.pdf","filesize":[{"value":"189.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-NAKAMICHI-N-kaken 2016-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45371/files/PH-PR-NAKAMICHI-N-kaken 2016-6p.pdf"},"version_id":"e6bf17dc-d8a7-4cfb-adea-bfef4e5323e9"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"膜輸送体OCTN1による神経細胞の機能制御機構とうつ病治療への応用に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"膜輸送体OCTN1による神経細胞の機能制御機構とうつ病治療への応用に関する研究"},{"subitem_title":"Elucidation of neural control mechanisms by solute carrier OCTN1 and the application to treatment of depression","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-20"},"publish_date":"2018-07-20","publish_status":"0","recid":"45371","relation_version_is_last":true,"title":["膜輸送体OCTN1による神経細胞の機能制御機構とうつ病治療への応用に関する研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:55:12.598708+00:00"}