{"created":"2023-07-27T06:51:48.297877+00:00","id":45372,"links":{},"metadata":{"_buckets":{"deposit":"add1835c-19f6-49d5-a2ab-bc7015765651"},"_deposit":{"created_by":18,"id":"45372","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45372"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045372","sets":["2812:2813:2821"]},"author_link":["78882","78883"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-24","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2010-2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"神経系前駆細胞(NPCs)に発現する溶質輸送担体(SLCトランスポーター)の生理学的役割を解明する目的で、SLCトランスポーターがNPCsの増殖能あるいは分化能に及ぼす影響を検討した。その結果、カルニチン/有機カチオントランスポーターOCTN1/SLC22A4が、NPCsに発現する主要な有機カチオントランスポーターであり、抗酸化物質エルゴチオネインの取り込みを介してNPCsの増殖能を抑制し、神経細胞への分化能を促進する可能性を示した。","subitem_description_type":"Abstract"},{"subitem_description":"To clarify the physiological role of solute carrier (SLC) transporters expressed in neural progenitor cells (NPCs), we examined effects of SLC transporters on proliferation and differentiation capacities in NPCs. As a result, it was suggested that carnitine/organic cation transporter OCTN1/SLC22A4 may be primary organic cation transporter in NPCs, and may suppress proliferation and promote neuronal differentiation of NPCs via uptake of the antioxidant ergothioneine.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22590081, 研究期間(年度):2010-2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「SLCトランスポーターによる神経系前駆細胞の増殖・分化能制御」課題番号22590081\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22590081/22590081seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051709","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域薬学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10401895"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10401895","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590081/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590081/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22590081/22590081seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22590081/22590081seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-20"}],"displaytype":"detail","filename":"PH-PR-NAKAMICHI-N-kaken 2013-6p.pdf","filesize":[{"value":"410.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-NAKAMICHI-N-kaken 2013-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45372/files/PH-PR-NAKAMICHI-N-kaken 2013-6p.pdf"},"version_id":"5f23e3a4-42b2-44de-87c4-95c8a431076e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"SLCトランスポーターによる神経系前駆細胞の増殖・分化能制御","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"SLCトランスポーターによる神経系前駆細胞の増殖・分化能制御"},{"subitem_title":"Modulation of proliferation and differentiation capacities by solute carrier transporters in neural progenitor cells","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-20"},"publish_date":"2018-07-20","publish_status":"0","recid":"45372","relation_version_is_last":true,"title":["SLCトランスポーターによる神経系前駆細胞の増殖・分化能制御"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:35:01.384637+00:00"}