{"created":"2023-07-27T06:51:48.606110+00:00","id":45379,"links":{},"metadata":{"_buckets":{"deposit":"e9794a0c-7bd5-4629-9abc-e658eff3b513"},"_deposit":{"created_by":18,"id":"45379","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45379"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045379","sets":["2812:2813:2818"]},"author_link":["562","78896"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05-24","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2014-04-01 - 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"偽造医薬品鑑別法の精度向上を目指して、ED治療薬Cialis錠（真正品9検体と偽造品32検体）を対象に、外観観察や非破壊的分光分析による鑑別とともに、不純物プロファイル分析による鑑別を試みた。不純物プロファイル分析により、含有成分とその量から、すべての偽造品が検出され、少なくとも7種の偽造パターンが存在した。真正品と偽造品において、外観、ラマンスペクトルおよび近赤外吸収スペクトルに差異が認められたが、真正品に酷似した偽造品も存在した。以上より、不純物プロファイル分析は、より高精度な偽造医薬品鑑別手法として、偽造医薬品の検出のみならず、偽造医薬品の流通経路の解明等にも役立つ可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"I wished to improve the accuracy of detection of falsified medicines. Impurity analyses were undertaken to detect falsified samples of Cialis(R) and compared with other analytical methods. Out of 41 samples, all falsified samples of Cialis(R) (n=32) were defined as “falsified medicine” by impurity profiling. These falsified samples of Cialis(R) could be categorized broadly into seven types according to the nature and amount of ingredients. Physical appearance (color, size, weight), Raman spectra (obtained from the tablet surface) and near-infrared spectrum (obtained from the whole tablet) of falsified samples of Cialis(R) were different from authentic samples. These findings suggest that impurity profiling could be a useful method for detection of falsified medicines in pharmaceutical distribution.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26870220, 研究期間(年度):2014-04-01 - 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「不純物プロファイル分析による偽造医薬品鑑別法の精度向上に関する研究」課題番号26870220\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26870220/26870220seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051716","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20565428"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20565428","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26870220/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26870220/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26870220/26870220seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26870220/26870220seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-20"}],"displaytype":"detail","filename":"PH-PR-YOSHIDA-N-kaken 2016-5p.pdf","filesize":[{"value":"273.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-YOSHIDA-N-kaken 2016-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45379/files/PH-PR-YOSHIDA-N-kaken 2016-5p.pdf"},"version_id":"5f352dea-1ad5-48a0-811a-4f1c35dd055d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"不純物プロファイル分析による偽造医薬品鑑別法の精度向上に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"不純物プロファイル分析による偽造医薬品鑑別法の精度向上に関する研究"},{"subitem_title":"Improvement of the method for detection of falsified medicines using impurity profiling","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-20"},"publish_date":"2018-07-20","publish_status":"0","recid":"45379","relation_version_is_last":true,"title":["不純物プロファイル分析による偽造医薬品鑑別法の精度向上に関する研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:55:09.429443+00:00"}