{"created":"2023-07-27T06:51:48.650497+00:00","id":45380,"links":{},"metadata":{"_buckets":{"deposit":"e79bf952-2563-4993-8803-3dfecefc70a4"},"_deposit":{"created_by":18,"id":"45380","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45380"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045380","sets":["2812:2813:2822"]},"author_link":["562","78896"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-25","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2010-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、がん化学療法における医薬品使用の安全性を確立することを目的として、抗がん薬と漢方薬を含む併用薬の使用実態を調査し、併用される漢方薬が抗がん薬の安全性に及ぼす影響を評価した。その結果、paclitaxelまたはirinotecanを使用した患者においてCommon Terminology Criteria for Adverse Events v4. 0のgrade3以上の血小板減少の発現と大建中湯または半夏瀉心湯の併用にそれぞれ有意な関連性が認められた他、一部の漢方薬の併用が骨髄抑制、電解質異常、肝機能検査値異常等の発現に影響を及ぼす可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"The aim of this study was to describe utilization of anticancer drugs and concomitant medicines including Kanpo medicines, and evaluate safety of concomitant Kampo medicines in chemotherapy. As a result, Co-administration of Daikenchuto or Hangeshashinto, in patients treated with paclitaxel or irinotecan, respectively, showed significant association with decrease of platelet count over grade 3 based on Common Terminology Criteria for Adverse Events v4. 0 criteria. In addition, some of co-administrated Kampo medicines could affect occurrence of adverse effects, such as myelosuppression, electrolyte abnormality, or hepatic dysfunction.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22790511, 研究期間(年度):2010-2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「がん化学療法における併用薬の使用実態調査と相互作用の予測に基づく安全性の確立」課題番号22790511\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22790511/22790511seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051717","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20565428"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20565428","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790511/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790511/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22790511/22790511seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22790511/22790511seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-20"}],"displaytype":"detail","filename":"PH-PR-YOSHIDA-N-kaken 2012-5p.pdf","filesize":[{"value":"218.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-YOSHIDA-N-kaken 2012-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45380/files/PH-PR-YOSHIDA-N-kaken 2012-5p.pdf"},"version_id":"7d7f3a6d-f8b9-4b18-bc7e-f5b253bd4b55"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"がん化学療法における併用薬の使用実態調査と相互作用の予測に基づく安全性の確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"がん化学療法における併用薬の使用実態調査と相互作用の予測に基づく安全性の確立"},{"subitem_title":"During utilization study and safety evaluation based on prediction approach for drug interactions in chemotherapy","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-20"},"publish_date":"2018-07-20","publish_status":"0","recid":"45380","relation_version_is_last":true,"title":["がん化学療法における併用薬の使用実態調査と相互作用の予測に基づく安全性の確立"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:27:28.196537+00:00"}