{"created":"2023-07-27T06:51:48.826786+00:00","id":45384,"links":{},"metadata":{"_buckets":{"deposit":"c53d5895-b5ce-49c2-aff1-fb91e761ddb8"},"_deposit":{"created_by":18,"id":"45384","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45384"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045384","sets":["2812:2813:2818"]},"author_link":["154","13878"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-09-15","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2014-04-01 - 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究ではタンパク質の絶対定量値を取得できる独自のプロテオミクス技術を用いた新規の膠芽腫サブタイプ分類の樹立を試みた。相互排他的な発現パターンを示すEGFR, ERBB2, PDGFRαに着目し、初発膠芽腫をEGFR群25例、PDGFRα群11例、ERBB2群7例に分類した。PFS中央値はそれぞれ8.3, 12.8, 37ヶ月で、OS中央値はそれぞれ16.1, 17.9, 25.7ヶ月であり、ERBB2群でPFS, OSが延長する傾向があった。以上の結果から、絶対定量プロテオミクスによるチロシンキナーゼの絶対発現量に基づいた膠芽腫のサブタイプ分類が可能であると考えられた。","subitem_description_type":"Abstract"},{"subitem_description":"The purpose of this study is to attempt to classify GBM subtypes based on the molecular profile determined by absolute quantitative proteomics and to investigate its clinical significance. GBMs in our study harbored mutually exclusive dominant expression of three RTKs; EGFR, PDGFRα and ERBB2. Therefore, we propose a subclassification of GBM with respect to the dominant expression of these proteins; EGFR (n=25), PDGFRα (n=11) and ERBB2 (n=7). PFS and OS tended to be longer in ERBB2 group in comparison with EGFR and PDGFRα group. Molecular subclassification of GBM based on the absolute quantitative proteomics reflects the clinical behavior and might have clinical significance.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26670638, 研究期間(年度):2014-04-01 - 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「標的タンパク発現プロファイルに基づく新規膠芽腫分類の試み」課題番号26670638\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26670638/26670638seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051721","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20334774"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20334774","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670638/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670638/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26670638/26670638seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26670638/26670638seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-20"}],"displaytype":"detail","filename":"ME-PR-NAKADA-M-kaken 2016-4p.pdf","filesize":[{"value":"557.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NAKADA-M-kaken 2016-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45384/files/ME-PR-NAKADA-M-kaken 2016-4p.pdf"},"version_id":"c76ebe5f-14cb-4035-9534-c4603fa31590"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"標的タンパク発現プロファイルに基づく新規膠芽腫分類の試み","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"標的タンパク発現プロファイルに基づく新規膠芽腫分類の試み"},{"subitem_title":"Molecular subclassification of glioblastoma based on the absolute quantitative proteomics","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-20"},"publish_date":"2018-07-20","publish_status":"0","recid":"45384","relation_version_is_last":true,"title":["標的タンパク発現プロファイルに基づく新規膠芽腫分類の試み"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:55:05.541124+00:00"}