{"created":"2023-07-27T06:51:48.959559+00:00","id":45387,"links":{},"metadata":{"_buckets":{"deposit":"690ff5dc-aa6a-4760-a65b-18a7fc3cf736"},"_deposit":{"created_by":18,"id":"45387","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45387"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045387","sets":["2812:2813:2823"]},"author_link":["154","13878"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-04-13","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2009-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 若手研究(A) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、幹細胞様グリオーマ細胞の高い浸潤能を規定する分子を探索した。グリオーマ組織中のCD133陽性細胞において普遍的にintegrin α3が高発現していることを見出した。ヒト膠芽腫組織において、浸潤グリオーマ細胞にintegrin α3の局在を認めた。Integrin α3の発現とグリオーマ細胞の浸潤能は正の相関を示し、その下流のシグナルとしてextracellular signal-regulated kinase(ERK)1/2が示された。integrin α3はERK1/2の活性を介して幹細胞様グリオーマ細胞の遊走・浸潤能を亢進させることが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Glioma stem-like cells are shown to be invasive but its mechanism remains to be elucidated. In this study we demonstrate the function of integrin in glioma stem-like cell invasion. The expression profile of integrin family in CD133+ and - cells was determined. Integrin α3 was overexpressed in CD133+ cells compared with CD133- cells. Immunohistochemistry demonstrated the localization of integrin alpha3 in invading glioblastoma cells. The activity of glioma cell invasion was associated with the expression level of integrin α3. The migration activity of glioma cell lines was linked to the phosphorylation level of ERK (extracellular signal-regulated kinase) 1/2. Our results suggest that endogenous integrin alpha3 contributes the invasive nature of glioma stem-like cells, which renders integrin alpha3 as a prime candidate for anti-invasion therapy for glioblastoma.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:21689038, 研究期間(年度):2009-2010","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「グリオーマ幹細胞の浸潤関連分子の同定と機能解析」課題番号21689038\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21689038/21689038seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051724","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20334774"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20334774","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21689038/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21689038/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21689038/21689038seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21689038/21689038seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-20"}],"displaytype":"detail","filename":"ME-PR-NAKADA-M-kaken 2011-5p.pdf","filesize":[{"value":"550.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NAKADA-M-kaken 2011-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45387/files/ME-PR-NAKADA-M-kaken 2011-5p.pdf"},"version_id":"52b6a593-af57-46bd-a3db-a3aadaa7817c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"グリオーマ幹細胞の浸潤関連分子の同定と機能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"グリオーマ幹細胞の浸潤関連分子の同定と機能解析"},{"subitem_title":"The identification of invasion associated genes in glioma stem cell","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-20"},"publish_date":"2018-07-20","publish_status":"0","recid":"45387","relation_version_is_last":true,"title":["グリオーマ幹細胞の浸潤関連分子の同定と機能解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:20:25.478532+00:00"}