{"created":"2023-07-27T06:51:49.267755+00:00","id":45394,"links":{},"metadata":{"_buckets":{"deposit":"0f69167c-e24f-465e-8444-e0560b5c8f05"},"_deposit":{"created_by":18,"id":"45394","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45394"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045394","sets":["2812:2813:2817"]},"author_link":["2325","22397"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-04-13","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2014-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究により、マウス脊椎への放射線照射後に硬膜外腔の繊維化（fibrosis）が誘発されることが確認され、fibrosis発生の中心的役割を果たすとされるサイトカイン、TGF-β1の過剰発現も認められた。また、髄膜の透過性に強く関与するくも膜バリア細胞層が放射線照射後に菲薄化することが確認された。これらの放射線障害は、照射後の脊椎手術における合併症発生（硬膜損傷や髄液漏）の一因になり得る。","subitem_description_type":"Abstract"},{"subitem_description":"This study confirms that epidural fibrosis is induced in the late stages after high-dose irradiation in mice, and that overexpression of TGF-β1 occurs in a manner similar to radiation-induced fibrosis in other tissue. Additionally, thinning of the ABC was observed in the late stages after irradiation. Thus, consideration should be given to the possibility that these phenomena can occur as radiation-induced injuries of the spine.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26462233, 研究期間(年度):2014-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「放射線照射が硬膜に及ぼす影響: 照射後髄液漏の原因究明」研究成果報告書　課題番号26462233\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26462233/26462233seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051731","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70334779"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70334779","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26462233/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26462233/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26462233/26462233seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26462233/26462233seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-20"}],"displaytype":"detail","filename":"ME-PR-MURAKAMI-H-kaken 2017-4p.pdf","filesize":[{"value":"589.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MURAKAMI-H-kaken 2017-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45394/files/ME-PR-MURAKAMI-H-kaken 2017-4p.pdf"},"version_id":"b213a2b0-30ba-4e12-b30a-a8282c96ac34"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"放射線照射が硬膜に及ぼす影響: 照射後髄液漏の原因究明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"放射線照射が硬膜に及ぼす影響: 照射後髄液漏の原因究明"},{"subitem_title":"Effects of Radiation on Spinal Dura Mater and Surrounding Tissue in Mice","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-20"},"publish_date":"2018-07-20","publish_status":"0","recid":"45394","relation_version_is_last":true,"title":["放射線照射が硬膜に及ぼす影響: 照射後髄液漏の原因究明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:25:45.215180+00:00"}