{"created":"2023-07-27T06:51:50.014694+00:00","id":45411,"links":{},"metadata":{"_buckets":{"deposit":"e3985765-b5e8-42ec-99a9-68bf19473b67"},"_deposit":{"created_by":18,"id":"45411","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45411"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045411","sets":["2812:2813:2817"]},"author_link":["2857","78918"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-06","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2014-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Lect2ノックアウトマウスにおける骨形態計測を行い、野生型マウスよりも骨量が減少していることが分かった。血清中の骨代謝マーカーを調べると、破骨細胞活性化マーカーTRAP5bの上昇がLect2 KOマウスでみられた。細胞レベルでも破骨細胞では、Lect2添加によってマクロファージから成熟破骨細胞への分化が抑制されることが分かった。骨芽細胞では分化段階には大きな影響がみられなかった。しかしながら、卵巣を摘出した閉経後骨粗鬆症モデルでは、野生型とLect2 KOマウスの骨量減少の程度に差は無かった。2年間飼育した老化マウスでは骨量と共にLect2が減少していることが分かった。","subitem_description_type":"Abstract"},{"subitem_description":"We measured the bone morphology in Lect 2 knockout mice and found that the bone mass decreased as compared with the wild type mouse. Examination of bone metabolism markers in serum showed an increase in osteoclast activation marker TRAP 5b in Lect 2 KO mice. Even at the cellular level, osteoclasts were found to inhibit the differentiation of macrophages into mature osteoclasts by addition of Lect 2. In osteoblasts, there was no significant effect on the differentiation stage. However, in the postmenopausal osteoporosis model from which the ovaries were removed, there was no difference in the extent of bone loss in wild type and Lect 2 KO mice.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26461377, 研究期間(年度):2014-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「肝臓から分泌されるサイトカインの骨粗鬆症への影響」研究成果報告書　課題番号26461377\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26461377/26461377seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健学総合研究科","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051748","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80419150"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80419150","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26461377/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26461377/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26461377/26461377seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26461377/26461377seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-23"}],"displaytype":"detail","filename":"ME-PR-ISHII-K-kaken 2017-4p.pdf","filesize":[{"value":"314.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-ISHII-K-kaken 2017-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45411/files/ME-PR-ISHII-K-kaken 2017-4p.pdf"},"version_id":"5244214a-7ee9-4449-b144-4a13fb4c07f1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肝臓から分泌されるサイトカインの骨粗鬆症への影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝臓から分泌されるサイトカインの骨粗鬆症への影響"},{"subitem_title":"Cytokines secreted from the liver affect bone mass","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-23"},"publish_date":"2018-07-23","publish_status":"0","recid":"45411","relation_version_is_last":true,"title":["肝臓から分泌されるサイトカインの骨粗鬆症への影響"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:25:43.860107+00:00"}