{"created":"2023-07-27T06:51:50.102345+00:00","id":45413,"links":{},"metadata":{"_buckets":{"deposit":"86e75698-4737-4c77-9cfd-adf49186759a"},"_deposit":{"created_by":18,"id":"45413","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45413"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045413","sets":["2812:2813:2816"]},"author_link":["74242","339"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-25","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2016-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究において我々は、肝細胞癌組織浸潤免疫細胞の発現遺伝子解析によって、免疫関連分子の発現レベルが症例ごとに大きく異なっていることを明らかにした。これらの違いは、特に肝細胞癌の背景肝疾患に影響され、非アルコール性脂肪肝炎(NASH)由来の肝細胞癌症例ではB型肝炎ウイルス、C型肝炎ウイルス由来の肝細胞癌に比べて、免疫関連分子の発現が低下しており、免疫細胞プロファイルにも大きな違いが認められた。また、NASH関連肝細胞癌では他の二者に比べて、腫瘍抗原特異的なT細胞のfrequencyが低く、こうしたT細胞の免疫応答は特定の免疫細胞プロファイルと相関を認めた。","subitem_description_type":"Abstract"},{"subitem_description":"In this study, we identified that the type and expression levels of immune molecules expressed in tumor infiltrating immune cells are different in each hepatocellular carcinoma (HCC) patient. We also identified that the differences are deeply associated with the etiology of HCC and the expression levels of many immune molecules in non-alcoholic steatohepatitis (NASH)-related HCC patients are lower than those in hepatitis B or C-related HCC patients. In addition, immune cell profiles are also different in the 3 groups. The frequency of tumor-associated antigen-specific T cells is lower in NASH-related HCC patients compared with that of other 2 groups and it is correlated with the specific immune cell profiles.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16K15425, 研究期間(年度):2016-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「Immunomeのシングルセル解析に基づいた肝癌新規分類法の確立」課題番号16K15425\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K15425/16K15425seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051750","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=90345611"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=90345611","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K15425/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K15425/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K15425/16K15425seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K15425/16K15425seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-19"}],"displaytype":"detail","filename":"ME-PR-MIZUKOSHI-E-kaken 2018-6p.pdf","filesize":[{"value":"83.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MIZUKOSHI-E-kaken 2018-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45413/files/ME-PR-MIZUKOSHI-E-kaken 2018-6p.pdf"},"version_id":"8191bc6f-7f96-426a-94e1-ae195a41c187"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"Immunomeのシングルセル解析に基づいた肝癌新規分類法の確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Immunomeのシングルセル解析に基づいた肝癌新規分類法の確立"},{"subitem_title":"New classification of hepatocellular carcinoma by single cell analysis of immunome","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-19"},"publish_date":"2019-04-19","publish_status":"0","recid":"45413","relation_version_is_last":true,"title":["Immunomeのシングルセル解析に基づいた肝癌新規分類法の確立"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:58:44.691549+00:00"}