{"created":"2023-07-27T06:51:50.145878+00:00","id":45414,"links":{},"metadata":{"_buckets":{"deposit":"d12c0c6e-b576-419a-82c1-0f181862e021"},"_deposit":{"created_by":18,"id":"45414","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45414"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045414","sets":["2812:2813:2818"]},"author_link":["74242","339"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-13","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2013-04-01 - 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mizukoshi, Eishiro"}],"nameIdentifiers":[{"nameIdentifier":"74242","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90345611","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90345611"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では肝細胞癌患者に対する癌免疫療法の１つとして、細胞傷害性Ｔ細胞レセプターを用いることによって、より効率的かつ強力に癌免疫を誘導できる手法の開発を行った。\n本研究成果として、ペプチドワクチンを投与した患者において誘導される癌抗原に特異的な細胞傷害性Ｔ細胞の特徴を明らかにした。また、肝細胞癌の免疫治療に有用と思われるＴ細胞レセプターの候補を取得し、同レセプターを用いた癌免疫療法の臨床試験を行うための基盤情報を整備した。","subitem_description_type":"Abstract"},{"subitem_description":"In this study, we tried to develop an immunological method to induce a stronger and more efficient cancer immunity using cytotoxic T cell receptor as a cancer immunotherapy for hepatocellular carcinoma patients.\nWe characterized the cancer antigen-specific cytotoxic T cells induced by peptide vaccine in hepatocellular carcinoma patients. In addition, we could obtain some candidates of cytotoxic T cell receptors useful for immunotherapy of hepatocellular carcinoma and equipped the basic informations to perform clinical studies using the cytotoxic T cell receptors.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25460984, 研究期間(年度):2013-04-01 - 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「細胞傷害性T細胞レセプターを用いた肝細胞癌免疫治療に関する基礎的検討」課題番号25460984\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25460984/25460984seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051751","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=90345611"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=90345611","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25460984/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25460984/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25460984/25460984seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25460984/25460984seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"水腰, 栄四郎"}],"nameIdentifiers":[{"nameIdentifier":"339","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90345611","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90345611"},{"nameIdentifier":"90345611","nameIdentifierScheme":"金沢大学研究者情報","nameIdentifierURI":"http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=90345611"},{"nameIdentifier":"90345611","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000090345611"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-23"}],"displaytype":"detail","filename":"ME-PR-MIZUKOSHI-E-kaken 2016-4p.pdf","filesize":[{"value":"82.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MIZUKOSHI-E-kaken 2016-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45414/files/ME-PR-MIZUKOSHI-E-kaken 2016-4p.pdf"},"version_id":"1b863835-b926-4d9a-8135-454b23436f47"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"細胞傷害性T細胞レセプターを用いた肝細胞癌免疫治療に関する基礎的検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"細胞傷害性T細胞レセプターを用いた肝細胞癌免疫治療に関する基礎的検討"},{"subitem_title":"Basic study of immunotherapy for hepatocellular carcinoma by cytotoxic T cell receptor","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-23"},"publish_date":"2018-07-23","publish_status":"0","recid":"45414","relation_version_is_last":true,"title":["細胞傷害性T細胞レセプターを用いた肝細胞癌免疫治療に関する基礎的検討"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:44:41.992827+00:00"}