{"created":"2023-07-27T06:51:50.189943+00:00","id":45415,"links":{},"metadata":{"_buckets":{"deposit":"c1206aee-3ef0-4501-afd1-3c8501b01816"},"_deposit":{"created_by":18,"id":"45415","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45415"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045415","sets":["2812:2813:2821"]},"author_link":["74242","339"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2010-2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では肝細胞癌の免疫療法に有用と考えられるペプチドワクチンの開発を行った。その結果、以下に記載する成果が得られた。1)肝細胞癌が発現するアルファフェトプロテイン(AFP)とヒトテロメラーゼ逆転写酵素(hTERT)におけるヘルパーT細胞エピトープを同定した。2)同エピトープに対する免疫反応が肝細胞癌患者の末梢血リンパ球において確認された。3)同エピトープのアミノ酸配列をもつペプチドワクチンを開発した。","subitem_description_type":"Abstract"},{"subitem_description":"In the present study, we tried to develop immunotherapy for hepatocellular carcinoma (HCC) by peptide vaccine. The following results were obtained from this study. 1) The helper T cell (HTL) epitopes in AFP and hTERT were identified. 2) Immune responses against these HTL epitopes in peripheral blood mononuclear cells of HCC patients were observed. 3) Peptide vaccines encoding amino acid sequences in the HTL epitopes were developed based on the above results.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22590723, 研究期間(年度):2010-2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「ペプチドワクチンを用いた肝細胞癌免疫療法の開発」課題番号22590723\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22590723/22590723seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051752","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=90345611"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=90345611","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590723/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590723/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22590723/22590723seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22590723/22590723seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-23"}],"displaytype":"detail","filename":"ME-PR-MIZUKOSHI-E-kaken 2013-5p.pdf","filesize":[{"value":"404.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MIZUKOSHI-E-kaken 2013-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45415/files/ME-PR-MIZUKOSHI-E-kaken 2013-5p.pdf"},"version_id":"906adccf-d588-4dbe-8a95-aef8a2b65d27"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ペプチドワクチンを用いた肝細胞癌免疫療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ペプチドワクチンを用いた肝細胞癌免疫療法の開発"},{"subitem_title":"Development of immunotherapy for hepatocellular carcinoma by peptide vaccine","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-23"},"publish_date":"2018-07-23","publish_status":"0","recid":"45415","relation_version_is_last":true,"title":["ペプチドワクチンを用いた肝細胞癌免疫療法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:34:57.252474+00:00"}