{"created":"2023-07-27T06:51:50.365801+00:00","id":45419,"links":{},"metadata":{"_buckets":{"deposit":"344fd4ca-75f7-425a-97f9-6aa1a7888d73"},"_deposit":{"created_by":18,"id":"45419","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45419"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045419","sets":["2812:2813:2819"]},"author_link":["78926","78925"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-06-02","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2013-04-01 - 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 研究活動スタート支援 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kawahara, Hironori"}],"nameIdentifiers":[{"nameIdentifier":"78926","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00424177","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00424177"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Exosomeは種々の細胞から分泌される小胞であり、神経系においても新たな細胞間情報伝達手段であると考えられている。しかし、特に刺激依存的なneuronal exosomeの伝播・情報伝達機構は全く明らかにされていない。そこで、マウス初代神経培養からIP3刺激依存的に分泌されるexosomeから新規lncRNAsと蛋白質を網羅的に同定した。さらに、Rpn1がexosomeを介したα-synucleinの伝播と伝播先のglia細胞での発現増強を誘導する分子であることを明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"Exosome is not only signal small vesicle which is utilized as cell-cell communication in various cells but also in neuronal cells. However, it remains unclear that the mechanisms by which neuronal exosomes are propagated within neuronal cells, particularly under IP3-stimulation. Novel lncRNAs (long non-coding RNAs) and proteins which were incorporated into IP3-stimulated exosomes were identified in mouse primary neurons. α-synuclein was efficiently incorporated into exosomes by Rpn1, and then efficiently transferred to glia cells via exosomes.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号: 25890012, 研究期間 (年度): 2013-08-30 – 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「神経系exosomeに内包する新規レビー小体認知症関連ncRNAの同定と機能解明」課題番号25890012\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25890012/25890012seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系 / 大阪大学","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051756","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00424177"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00424177","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25890012/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25890012/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25890012/25890012seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25890012/25890012seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河原, 裕憲"}],"nameIdentifiers":[{"nameIdentifier":"78925","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00424177","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00424177"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-23"}],"displaytype":"detail","filename":"ME-PR-KAWAHARA-H-kaken 2015-4p.pdf","filesize":[{"value":"228.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KAWAHARA-H-kaken 2015-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45419/files/ME-PR-KAWAHARA-H-kaken 2015-4p.pdf"},"version_id":"a03f46aa-5644-47ed-aa72-1947efde2c58"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"神経系exosomeに内包する新規レビー小体認知症関連ncRNAの同定と機能解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"神経系exosomeに内包する新規レビー小体認知症関連ncRNAの同定と機能解明"},{"subitem_title":"Identification and elucidation of functional relationship between neuronal exosomal ncRNA and Lewy body dementia","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-23"},"publish_date":"2018-07-23","publish_status":"0","recid":"45419","relation_version_is_last":true,"title":["神経系exosomeに内包する新規レビー小体認知症関連ncRNAの同定と機能解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:48:35.499829+00:00"}