{"created":"2023-07-27T06:51:50.542099+00:00","id":45423,"links":{},"metadata":{"_buckets":{"deposit":"ce087db4-9d56-48d3-a8b5-0d888093558b"},"_deposit":{"created_by":18,"id":"45423","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45423"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045423","sets":["2812:2813:2821"]},"author_link":["78930","78929"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-06-01","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2010-2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hanayama, Rikinari"}],"nameIdentifiers":[{"nameIdentifier":"78930","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40403191","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40403191"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"アポトーシス細胞は、ホスファチジルセリン(PS)を細胞膜の外側に提示し、これをマクロファージなどの食細胞が認識して貪食する。私たちは、マクロファージ上の蛋白質TIM4がこのPSと結合することによりアポトーシス細胞をマクロファージに繋ぎ止める一方、マクロファージから分泌されるMFG-E8がPSと結合し、マクロファージ上のインテグリンと橋渡しをすることにより、アポトーシス細胞を取り込むことを見出した。","subitem_description_type":"Abstract"},{"subitem_description":"Apoptotic cells are engulfed by macrophages by recognizing phosphatidylserine (PS). We found that Tim4 receptor on macrophages tethers apoptotic cells to macrophages by binding PS, and MFG-E8 secreted from macrophages binds to PS and stimulates the engulfment by binding to integrin on macrophages.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22790210, 研究期間(年度):2010-2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「食細胞によるアポトーシス細胞貧食除去の動作原理の解明」課題番号22790210\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22790210/22790210seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051760","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学新学術創成研究機構ナノ生命科学研究所 / 大阪大学"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40403191"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40403191","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790210/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790210/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22790210/22790210seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22790210/22790210seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"華山, 力成"}],"nameIdentifiers":[{"nameIdentifier":"78929","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40403191","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40403191"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-23"}],"displaytype":"detail","filename":"ME-PR-HANAYAMA-R-kaken 2013-4p.pdf","filesize":[{"value":"322.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-HANAYAMA-R-kaken 2013-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45423/files/ME-PR-HANAYAMA-R-kaken 2013-4p.pdf"},"version_id":"321163de-4c89-494f-9c36-7295edca1680"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"食細胞によるアポトーシス細胞貧食除去の動作原理の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"食細胞によるアポトーシス細胞貧食除去の動作原理の解明"},{"subitem_title":"The Dynamic mechanism of phagocytosis of apoptotic cells","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-23"},"publish_date":"2018-07-23","publish_status":"0","recid":"45423","relation_version_is_last":true,"title":["食細胞によるアポトーシス細胞貧食除去の動作原理の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:54:06.213331+00:00"}