{"created":"2023-07-27T06:51:50.761837+00:00","id":45428,"links":{},"metadata":{"_buckets":{"deposit":"00413155-91ea-4356-92e2-a8ee96f4a8e4"},"_deposit":{"created_by":18,"id":"45428","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45428"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045428","sets":["2812:2813:2818"]},"author_link":["78939","2269"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-22","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2014-03-31 - 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々はセリンスレオニンキナーゼファミリーであるglycogen synthase kinase 3β(\nGSK3β）を阻害すると膠芽腫細胞の増殖が抑制されることを報告している。GSK3β阻害効果を有する既存薬剤4剤を用いた検討では、in vitro、in vivoのいずれにおいても膠芽腫細胞の増殖・遊走・浸潤が抑制された。また、nestin陽性細胞の低下を認め、GSK3β阻害による膠芽腫細胞の幹細胞性の低下が示唆された。膠芽腫患者の手術検体において、活性化型GSK3βの発現と予後の関連を検討したが、高発現群で有意に予後が悪く、GSK3βが膠芽腫の予後不良因子であることが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"We have reported that inhibition of glycogen synthase kinase 3β(GSK3β）supresses proliferation of glioblastoma cell.Existing drugs which have inhibitory effect for GSk3β inhibit cell proliferation and invasion of glioblastoma in vitro and in vivo.These drugs supress nestin positive cells, that means reduction of stemness og glioblastoma.According to analysis of expression of active form of GSK3β for surgical spiecimens, progression free survival and overall survival of patients with high level expression is worse than patients with low expression.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26861142, 研究期間(年度):2014-03-31 - 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「GSK3βを分子標的とする神経膠芽腫治療の基礎基盤の構築」課題番号26861142\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26861142/26861142seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院脳神経外科","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051765","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80624874"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80624874","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26861142/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26861142/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26861142/26861142seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26861142/26861142seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-23"}],"displaytype":"detail","filename":"ME-PR-MIYASHITA-K-kaken 2016-4p.pdf","filesize":[{"value":"165.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MIYASHITA-K-kaken 2016-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45428/files/ME-PR-MIYASHITA-K-kaken 2016-4p.pdf"},"version_id":"36c07301-5505-45a2-bf43-89b1be6deeb2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"GSK3βを分子標的とする神経膠芽腫治療の基礎基盤の構築","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"GSK3βを分子標的とする神経膠芽腫治療の基礎基盤の構築"},{"subitem_title":"Constraction of basis of glioblastoma treatment targeting for GSK3beta","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-23"},"publish_date":"2018-07-23","publish_status":"0","recid":"45428","relation_version_is_last":true,"title":["GSK3βを分子標的とする神経膠芽腫治療の基礎基盤の構築"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:54:57.338495+00:00"}