{"created":"2023-07-27T06:51:50.937371+00:00","id":45433,"links":{},"metadata":{"_buckets":{"deposit":"1b83805b-615a-4f58-9195-e7bc8a18e636"},"_deposit":{"created_by":18,"id":"45433","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45433"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045433","sets":["2812:2813:2825"]},"author_link":["2544","12082"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-05-15","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2007-2008","bibliographic_titles":[{"bibliographic_title":"平成20(2008)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2008 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hayashi, Yasuhiko"}],"nameIdentifiers":[{"nameIdentifier":"12082","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50324124","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50324124"},{"nameIdentifier":"50324124","nameIdentifierScheme":"金沢大学研究者情報","nameIdentifierURI":"http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=50324124"},{"nameIdentifier":"50324124","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000050324124"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"悪性グリオーマでは細胞性浮腫を緩和するためにアクアポーリンの発現を増加させ、さらにはカテプシンBを活性化して腫瘍細胞が血管周囲腔に沿って増殖浸潤するという推論を証明することが実験の目的である。そこで、解糖系を活性化し、さらにsiRNAにてAQP-1を抑制すると細胞増殖は著しく抑制され、AQP-1 plasmidによる過剰発現細胞株を用いた系では、解糖系の活性、抑制に依らず細胞増殖には差はなかった。これは解糖系による細胞性腫脹の緩和と細胞増殖にAQP-1が大きな役割を果たしていることを示している。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19591666, 研究期間(年度):2007-2008","subitem_description_type":"Other"},{"subitem_description":"出典：「悪性グリオーマにおけるアクアポリンの機能解明とその抑制による新たな治療戦略」研究成果報告書　課題番号19591666\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19591666/19591666seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051770","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50324124"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50324124","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591666/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591666/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19591666/19591666seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19591666/19591666seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"林, 康彦"}],"nameIdentifiers":[{"nameIdentifier":"2544","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50324124","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50324124"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-23"}],"displaytype":"detail","filename":"HO-PR-HAYASHI-Y-kaken 2009-4p.pdf","filesize":[{"value":"205.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-HAYASHI-Y-kaken 2009-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45433/files/HO-PR-HAYASHI-Y-kaken 2009-4p.pdf"},"version_id":"7840ca21-dadb-4c06-992c-d14a4cdd12f7"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research 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