{"created":"2023-07-27T06:51:51.068690+00:00","id":45436,"links":{},"metadata":{"_buckets":{"deposit":"316e7c19-2d84-4e10-9dfe-4355235cf01f"},"_deposit":{"created_by":18,"id":"45436","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45436"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045436","sets":["2812:2813:2819"]},"author_link":["2354","20074"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-06-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2012-04-01 - 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"肝や脂肪組織などの末梢組織における体内時計（末梢時計）の障害は、2型糖尿病を初めとする生活習慣病の一因であることが示唆されている。そこで、末梢時計を標的とした生活習慣病の予防・治療法を開発するために、末梢時計の制御が可能な薬物をマウスモデルを用いて探索し、2型糖尿病治療薬であるエキセナチドには摂餌刺激よりも強力な末梢時計制御作用があることを見出した。また、空腹時血糖の日内リズムは直接的には肝の体内時計により制御されていることを明らかにし、糖代謝制御機構における末梢時計の関与を明確にした。","subitem_description_type":"Abstract"},{"subitem_description":"Recent studies have indicated that disrupted circadian clocks in peripheral tissues (peripheral clocks) are associated with the pathophysiology of lifestyle-related metabolic diseases including type 2 diabetes. To develop a strategy targeting peripheral clocks for treatment/prevention of metabolic diseases, whether exenatide could affect the rhythms of peripheral clocks was investigated in mice, and we found that exenatide modulates peripheral clocks more strongly than feeding. In addition, we evaluated the impact of peripheral clock in the liver and revealed that hepatic clock directly regulates the daily fasting blood glucose rhythm.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24590666, 研究期間(年度):2012-04-01 - 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「末梢体内時計を標的とした2型糖尿病の薬物療法の開発」課題番号24590666\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24590666/24590666seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系 / 自治医科大学","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051773","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50382875"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50382875","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24590666/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24590666/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24590666/24590666seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24590666/24590666seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-23"}],"displaytype":"detail","filename":"ME-PR-AODO-H-kaken 2015-4p.pdf","filesize":[{"value":"285.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-AODO-H-kaken 2015-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45436/files/ME-PR-AODO-H-kaken 2015-4p.pdf"},"version_id":"41fed4ae-6517-41a8-b61c-a0b09ae76523"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"末梢体内時計を標的とした2型糖尿病の薬物療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"末梢体内時計を標的とした2型糖尿病の薬物療法の開発"},{"subitem_title":"Development of pharmacological therapy targeting peripheral circadian clocks for treatment of type 2 diabetes","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-23"},"publish_date":"2018-07-23","publish_status":"0","recid":"45436","relation_version_is_last":true,"title":["末梢体内時計を標的とした2型糖尿病の薬物療法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:37:43.088715+00:00"}