{"created":"2023-07-27T06:51:51.112540+00:00","id":45437,"links":{},"metadata":{"_buckets":{"deposit":"760a0e07-e710-42e8-aaeb-d055bc31fa99"},"_deposit":{"created_by":18,"id":"45437","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45437"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045437","sets":["2812:2813:2823"]},"author_link":["2354","20074"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05-01","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2009-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ando, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"20074","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50382875","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50382875"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"末梢体内時計の生理的意義と制御機構を解明するために、肥満2型糖尿病モデルであるob/obマウスの体内時計を解析した。ob/obマウスの体内時計障害は、(1)中枢時計には認められず、末梢組織特異的に認められ、(2)代謝異常が出現する以前の3週齢時より存在し、(3)レプチンの短期間投与により改善した。したがって、末梢時計障害は代謝異常の結果としては生じていないこと、末梢時計の制御にはレプチンシグナルが重要であることが明らかとなった。","subitem_description_type":"Abstract"},{"subitem_description":"To elucidate the physiological significance and controlling mechanism of peripheral clocks, the biological clocks in obese diabetic ob/ob mice were studied. The impairment of circadian clocks in ob/ob mice was (1) found in the peripheral tissues, but not in the suprachiasmatic nucleus (central clock), (2) detectable before the development of metabolic abnormalities, and (3) improved by short-term treatment with leptin. These results suggest that the impairment of peripheral clocks is not a result of metabolic derangement and that leptin signaling is important for maintaining the peripheral clock functions.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「末梢体内時計の生理的・臨床的意義の解明と制御法の開発」課題番号21790880\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21790880/21790880seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系 / 自治医科大学","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051774","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50382875"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50382875","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790880/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790880/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21790880/21790880seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21790880/21790880seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"安藤, 仁"}],"nameIdentifiers":[{"nameIdentifier":"2354","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50382875","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50382875"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-23"}],"displaytype":"detail","filename":"ME-PR-AODO-H-kaken 2011-4p.pdf","filesize":[{"value":"309.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-AODO-H-kaken 2011-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45437/files/ME-PR-AODO-H-kaken 2011-4p.pdf"},"version_id":"9782cc46-63cb-4796-83bb-d1e8e7c8a7c8"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"末梢体内時計の生理的・臨床的意義の解明と制御法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"末梢体内時計の生理的・臨床的意義の解明と制御法の開発"},{"subitem_title":"Evaluation of the pathophysiological signicance of peripheral clocks and the development of methods of controlling them","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-23"},"publish_date":"2018-07-23","publish_status":"0","recid":"45437","relation_version_is_last":true,"title":["末梢体内時計の生理的・臨床的意義の解明と制御法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T06:00:30.026001+00:00"}