{"_buckets": {"deposit": "cbf11a9e-b84d-43a2-a4dd-417c5adc2d2b"}, "_deposit": {"created_by": 18, "id": "45439", "owners": [18], "pid": {"revision_id": 0, "type": "depid", "value": "45439"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00045439", "sets": ["2820"]}, "author_link": ["78949", "190"], "item_9_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2014-06-03", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "4p.", "bibliographicVolumeNumber": "2011-04-01 - 2014-03-31", "bibliographic_titles": [{"bibliographic_title": "平成25(2013)年度 科学研究費補助金 若手研究(A) 研究成果報告書"}, {"bibliographic_title": "2013 Fiscal Year Final Research Report", "bibliographic_titleLang": "en"}]}]}, "item_9_creator_33": {"attribute_name": "著者別表示", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Shinmyo, Yohei"}], "nameIdentifiers": [{"nameIdentifier": "78949", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "00418831", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=00418831"}]}]}, "item_9_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "draxinはサブプレート神経を含む大脳新皮質に強く、大脳腹側部と視床に弱く発現する。大脳新皮質に発現するdraxinが視床皮質軸索投射に重要であるかを検証するために、レスキュー実験を行った。pCAGGSプロモーター下にloxpを両端に持つβ-geoとさらに下流にdraxin-IRES-eGFPを持つトランスジェニックマウスを作成した。このマウスを用いてdraxinノックアウトマウスにおいて大脳新皮質特異的にdraxinの発現を誘導した結果、多くの視床皮質軸索が大脳新皮質に向かって投射する事が分かった。\nこの結果から、サブプレートを含む大脳新皮質に発現するdraxinの重要性が示唆された。", "subitem_description_type": "Abstract"}, {"subitem_description": "In this study, we have focused on Draxin functions in thalamocortical projections. It has long been recognized that neocortical pioneer axons from subplate neurons are essential for the guidance of thalamocortical projections. Draxin is strongly expressed in early-born cortical neurons, including subplate and Cajal-Retzius cells, and weakly expressed in the ventral telencephalon and dorsal thalamus. Draxin deficient mice showed severe defects in thalamocortical projections. Thalamic axons showed a pathfinding error in the internal capsule region at embryonic day 14.5, when cortical axon pathfinding still appeared normal.\nThis suggests that draxin has direct functions in thalamocortical projections. Furthermore, the thalamocortical phenotype in draxin-/- mice is sufficiently rescued by transgenic expression of draxin in the neocortex. These results suggest that draxin from neocortical pioneer neurons is required for the guidance of thalamocortical projections.", "subitem_description_type": "Abstract"}]}, "item_9_description_22": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "研究課題/領域番号:23680036, 研究期間(年度):2011-04-01 - 2014-03-31", "subitem_description_type": "Other"}, {"subitem_description": "出典：研究課題「軸索ガイダンス分子draxinが担う視床皮質軸索投射機構の解明」課題番号23680036\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23680036/23680036seika/）を加工して作成", "subitem_description_type": "Other"}]}, "item_9_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.24517/00051776", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_17": {"attribute_name": "公開者", "attribute_value_mlt": [{"subitem_publisher": "金沢大学医薬保健研究域医学系 / 熊本大学"}]}, "item_9_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "https://kaken.nii.ac.jp/search/?qm=00418831"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://kaken.nii.ac.jp/search/?qm=00418831", "subitem_relation_type_select": "URI"}}, {"subitem_relation_name": [{"subitem_relation_name_text": "https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23680036/"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23680036/", "subitem_relation_type_select": "URI"}}, {"subitem_relation_name": [{"subitem_relation_name_text": "https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23680036/23680036seika/"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23680036/23680036seika/", "subitem_relation_type_select": "URI"}}]}, "item_9_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "新明, 洋平"}], "nameIdentifiers": [{"nameIdentifier": "190", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "00418831", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=00418831"}, {"nameIdentifier": "00418831", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=00418831"}, {"nameIdentifier": "00418831", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000000418831"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-07-26"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ME-PR-SHINMYO-Y-kaken 2014-4p.pdf", "filesize": [{"value": "179.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 179200.0, "url": {"label": "ME-PR-SHINMYO-Y-kaken 2014-4p.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/45439/files/ME-PR-SHINMYO-Y-kaken 2014-4p.pdf"}, "version_id": "dbd4d849-299f-4164-9077-f9af82208249"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "軸索ガイダンス", "subitem_subject_scheme": "Other"}, {"subitem_subject": "視床皮質軸索投射", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "軸索ガイダンス分子draxinが担う視床皮質軸索投射機構の解明", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "軸索ガイダンス分子draxinが担う視床皮質軸索投射機構の解明"}, {"subitem_title": "Draxin roles in thalamocortical projections", "subitem_title_language": "en"}]}, "item_type_id": "9", "owner": "18", "path": ["2820"], "permalink_uri": "https://doi.org/10.24517/00051776", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-07-26"}, "publish_date": "2018-07-26", "publish_status": "0", "recid": "45439", "relation": {}, "relation_version_is_last": true, "title": ["軸索ガイダンス分子draxinが担う視床皮質軸索投射機構の解明"], "weko_shared_id": -1}