{"created":"2023-07-27T06:51:51.244513+00:00","id":45440,"links":{},"metadata":{"_buckets":{"deposit":"dc0fb819-d5ef-45ac-82ce-24919e0ca8fd"},"_deposit":{"created_by":18,"id":"45440","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45440"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045440","sets":["2812:2813:2823"]},"author_link":["78949","190"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-04-01","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2009-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shinmyo, Yohei"}],"nameIdentifiers":[{"nameIdentifier":"78949","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00418831","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00418831"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究の目的は、我々が発見した新規ガイダンス分子であるDraxinに着目し、非常に複雑な脳神経回路の形成メカニズムの一端を明らかにする事である。本研究では、Draxinがユニークな役割を果たすと考えられる脳梁形成と視床皮質軸索投射に着目した。視床皮質軸索と皮質視床軸索は内包で直接的に相互作用し、最終的な標的にお互いをガイドする。パイオニア軸索を発するサブプレート神経が視床皮質軸索投射に必須であることが明らかにされているが、その過程に関わるガイダンス分子は報告されていない。我々は、Draxinの機能に関して以下の事を明らかにした。1)Draxinノックアウトマウスの視床皮質軸索は内包までは到達するが、その後大脳新皮質に投射されず、一部は外包に異常に投射する。2)Draxinはサブプレート神経を含む大脳新皮質に強く発現する。3)Draxin-Alkaline Phosphatase (AP)タンパク質は視床皮質軸索に結合する事から、視床皮質神経細胞にDraxin受容体が発現すると考えられる。さらに、Draxinは視床組織片からの神経突起に結合し、その伸長を阻害する。4)Draxinノックアウトマウスにおけるサブプレート神経の形成は正常である。以上の結果から、サブプレート神経を含む大脳新皮質から分泌されるDraxinが視床皮質軸索の内包から大脳新皮質への投射に必須のガイダンス分子であると考えられた。脳梁形成に関しては、Draxinの反発活性を仲介する受容体がdccである事を明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"In this study, we focused on Draxin functions in corpus callosum formation and thalamocortical projections. We found that Draxin has a critical role for the projections of corticothalamic and thalamocortical axons. Draxin is strongly expressed in early-born cortical neurons, including subplate and Cajal-Retzius cells, and weakly expressed in the ventral telencephalon and dorsal thalamus. Draxin deficient mice showed severe defects in the guidance of these axons : thalamocortical and corticothalamic axons followed an ectopic route through the external capsule instead of projecting to the cortex and thalamus, respectively. We found that thalamic axons showed a pathfinding error in the internal capsule region at embryonic day 14.5, when cortical axon pathfinding still appeared normal. This suggests that primary defects in the thalamocortical axon pathfinding cause misprojection of cortical axons. In addition, we showed that Draxin binds to thalamocortical axons and has inhibitory effects for neurite outgrowth from thalamic explants. Thus, we propose that Draxin repulsion from the neocortex may be essential for proper guidance of thalamocortical axons. We also found that Draxin repulsion is mediated by a receptor, dcc in the callosal neurons.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:21700382, 研究期間(年度):2009-2010","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「脳梁と視床-皮質神経回路形成におけるDraxinシグナルの役割」課題番号21700382\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21700382/21700382seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系 / 熊本大学","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051777","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00418831"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00418831","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21700382/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21700382/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21700382/21700382seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21700382/21700382seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"新明, 洋平"}],"nameIdentifiers":[{"nameIdentifier":"190","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00418831","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00418831"},{"nameIdentifier":"00418831","nameIdentifierScheme":"金沢大学研究者情報","nameIdentifierURI":"http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=00418831"},{"nameIdentifier":"00418831","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000000418831"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-26"}],"displaytype":"detail","filename":"ME-PR-SHINMYO-Y-kaken 2011-6p.pdf","filesize":[{"value":"388.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SHINMYO-Y-kaken 2011-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45440/files/ME-PR-SHINMYO-Y-kaken 2011-6p.pdf"},"version_id":"adfe76fe-ee69-43dd-abf8-80ee59bbf25e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"脳梁と視床-皮質神経回路形成におけるDraxinシグナルの役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脳梁と視床-皮質神経回路形成におけるDraxinシグナルの役割"},{"subitem_title":"Roles of Draxin signaling in formation of the corpus callosum and thalamocortical projections","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-26"},"publish_date":"2018-07-26","publish_status":"0","recid":"45440","relation_version_is_last":true,"title":["脳梁と視床-皮質神経回路形成におけるDraxinシグナルの役割"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T06:04:05.702429+00:00"}