{"created":"2023-07-27T06:51:51.332005+00:00","id":45442,"links":{},"metadata":{"_buckets":{"deposit":"898b5b4f-f1ed-4833-a0a4-69a045492831"},"_deposit":{"created_by":18,"id":"45442","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45442"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045442","sets":["2812:2813:2820"]},"author_link":["23640","490"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-21","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2012-04-01 - 2014-03-31","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ES細胞の自己複製は、転写因子による制御が深く関わっている。本研究では、転写因子Oct3/4とクロマチン・リモデリング因子Baf53aの相関を解析した。Baf53aは未分化なES細胞に強く発現し、Oct3/4の発現停止数日後に発現が減少した。また、Baf53aはOct3/4のPOUドメインに相互作用していた。RNAiによるBaf53aの機能阻害実験から、Baf53aはES細胞の増殖能と、ヒストンH4のアセチル化に関与していることを見出した。以上からBaf53aはOct3/4と連携してES細胞の増殖能やエピゲノム状態維持に関わっていることが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Several transcription factors are involved in the self-renewal of ES cells. In the present study, I examined relationships between Oct3/4 (transcription factor) and Baf53a (chromatin remodeling factor). Baf53a mRNA expressed in the undifferentiated ES cells, and decreased after Oct3/4 repression. Also, Baf53a associated with the POU domain of Oct3/4. Loss of function experiment of Baf53a by RNAi revealed that Baf53a was involved in proliferation and acetylation of histon H4. Taken together, these results suggest that Baf53a, together with Oct3/4, is involved in proliferation and epigenomic maintenance of ES cells.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24790274, 研究期間(年度):2012-04-01 - 2014-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「Baf53aとOct3/4を介したES細胞の自己複製制御機構の解析」課題番号24790274\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24790274/24790274seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051779","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70532183"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70532183","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790274/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790274/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24790274/24790274seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24790274/24790274seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-23"}],"displaytype":"detail","filename":"ME-PR-AKAGI-T-kaken 2014-4p.pdf","filesize":[{"value":"283.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-AKAGI-T-kaken 2014-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45442/files/ME-PR-AKAGI-T-kaken 2014-4p.pdf"},"version_id":"06b6daef-7205-4739-a875-10c99d24f3de"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"Baf53aとOct3/4を介したES細胞の自己複製制御機構の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Baf53aとOct3/4を介したES細胞の自己複製制御機構の解析"},{"subitem_title":"Investigation of Baf53a and Oct3/4 in the self-renewal of ES cells","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-23"},"publish_date":"2018-07-23","publish_status":"0","recid":"45442","relation_version_is_last":true,"title":["Baf53aとOct3/4を介したES細胞の自己複製制御機構の解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:18:14.607221+00:00"}