{"created":"2023-07-27T06:51:51.463405+00:00","id":45445,"links":{},"metadata":{"_buckets":{"deposit":"6f0687fc-8c8a-440a-b23c-9ecab4e9b713"},"_deposit":{"created_by":18,"id":"45445","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45445"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045445","sets":["2812:2813:2823"]},"author_link":["20132","78955"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05-31","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2008-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"マウス後根神経節由来神経細胞との共存培養で活性化されるヒト微小血管内皮細胞(HMVEC)の遺伝子を同定した。低酸素状態によりHMVECの可溶型VEGF受容体1(可溶型Flt-1,sFlt-1)産生が顕著に抑制され、それがmRNA選択的3'端プロセシングによる可溶型mRNA産生が減少するためであることを明らかにした。内在性アミロイドベータ蛋白デコイ受容体(esRAGE)の発現がアルツハイマー病患者脳で低下していることを見出した。HMVECではmiR-21を筆頭として約20種のミクロRNAが発現していることを見出した。マウス胎児の脳と皮膚にレンチウイルスベクターでの遺伝子導入を行った。esRAGE定量法とesRAGEトランスジェニックマウスの特許出願を行った。","subitem_description_type":"Abstract"},{"subitem_description":"We identified genes which were reproducibly up-regulated in HMVEC by the co-culture with dorsal root ganglion neurons and human microvascular endothelial cells (HMVEC). We found that hypoxia down-regulated soluble VEGF receptor-1 (soluble Flt-1, sFlt-1) expression in HMVEC and identified cis-elements that regulated sFlt-1 mRNA 3'-end processing. We found significantly reduced expression of esRAGE, a decoy receptor for amyloid β, in the hippocampal tissues from Alzheimer's disease brains by immunohistochemical analysis. We revealed that HMVEC expressed over 20 microRNAs including miR21. We injected lentiviral vectors into embryonic mouse skin and brain, and confirmed the expression of the introduced genes. We developed an assay method for esRAGE mRNA and an esRAGE transgenic mouse, and applied for patents for them.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:20590290, 研究期間(年度):2008-2010","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「神経-血管相互作用による血管ネットワーク形成に関わる遺伝子群の探索と病理機能」課題番号20590290\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20590290/20590290seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051782","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系 / 金沢医科大学"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80240373"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80240373","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590290/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590290/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20590290/20590290seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20590290/20590290seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-23"}],"displaytype":"detail","filename":"ME-PR-YONEKURA-H-kaken 2011-6p.pdf","filesize":[{"value":"366.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-YONEKURA-H-kaken 2011-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45445/files/ME-PR-YONEKURA-H-kaken 2011-6p.pdf"},"version_id":"e2e1bdfa-5fcf-4f32-b624-349009131e6f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"神経-血管相互作用による血管ネットワーク形成に関わる遺伝子群の探索と病理機能","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"神経-血管相互作用による血管ネットワーク形成に関わる遺伝子群の探索と病理機能"},{"subitem_title":"Identification of genes involved in the vascular network formation through neuro-vascular interactions","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-23"},"publish_date":"2018-07-23","publish_status":"0","recid":"45445","relation_version_is_last":true,"title":["神経-血管相互作用による血管ネットワーク形成に関わる遺伝子群の探索と病理機能"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:20:19.815852+00:00"}