{"created":"2023-07-27T06:51:51.507192+00:00","id":45447,"links":{},"metadata":{"_buckets":{"deposit":"cad7e530-4d36-4731-b655-1826e61ef402"},"_deposit":{"created_by":18,"id":"45447","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45447"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045447","sets":["2812:2813:2818"]},"author_link":["78961","78959"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05-31","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2014-04-01 - 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"これまでの研究により、glyoxalase 1(GLO1)遺伝子プロモーター領域近傍に新規遺伝子多型が存在することを新たに見出した。この新規遺伝子多型が、GLO1の転写を著しく亢進させることが明らかとなり、遺伝子多型の存在とGLO1酵素活性とは正の相関をしていた。また、この遺伝子多型DNAと特異的に結合するたんぱくタンパク質の同定にも成功し、当該タンパク質の存在が遺伝子多型の示す転写亢進に不可欠であることも明らかとなった。当該タンパク質の存在によってヒストンがアセチル化されることも明らかとなり、遺伝子多型による転写亢進にはエピゲノム調節が重要な働きをしていることが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"A gene polymorphism in human glyoxalase 1 (GLO1) promoter region was newly identified and was found to significantly induce transcriptional expression of the GLO1 gene. The gene polymorphism was also positively correlated with the GLO1 enzyme activity. Furthermore, we identified associated proteins with the GLO1 gene polymorphism in the nuclear extracts, which is essential for transcriptional upregulation of GLO1 gene. Taken together, these results suggested that epigenetic regulation could play an important role in human GLO1 gene expression.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26860187, 研究期間(年度):2014-04-01 - 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「解毒酵素グリオキザレースIの新規転写発現調節機構の解明」課題番号26860187\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26860187/26860187seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051784","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50705522"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50705522","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26860187/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26860187/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26860187/26860187seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26860187/26860187seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-23"}],"displaytype":"detail","filename":"ME-PR-HARASHIMA-A-kaken 2016-4p.pdf","filesize":[{"value":"261.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-HARASHIMA-A-kaken 2016-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45447/files/ME-PR-HARASHIMA-A-kaken 2016-4p.pdf"},"version_id":"552ce4c1-136c-4430-a5f9-63da6ba52317"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"解毒酵素グリオキザレースIの新規転写発現調節機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"解毒酵素グリオキザレースIの新規転写発現調節機構の解明"},{"subitem_title":"Analysis of novel transcription regulation mechanism of glyoxalase 1","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-23"},"publish_date":"2018-07-23","publish_status":"0","recid":"45447","relation_version_is_last":true,"title":["解毒酵素グリオキザレースIの新規転写発現調節機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:54:58.571705+00:00"}