{"created":"2023-07-27T06:51:51.594699+00:00","id":45449,"links":{},"metadata":{"_buckets":{"deposit":"7324568b-1f36-4535-946d-ab8246eacec0"},"_deposit":{"created_by":18,"id":"45449","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45449"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045449","sets":["2812:2813:2819"]},"author_link":["100","24836"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-06-15","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2012-04-01 - 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"糖尿病血管障害の新規予防・治療法の開発を目指した。標的とするのは、パターン認識受容体の一つで糖尿病血管合併症に関わる膜型受容体RAGE（receptor for advanced glycation end-products）であり、その受容体のectodomain sheddingの誘発によりシグナル伝達型RAGEを切断し、デコイ受容体として働く可溶型RAGE（soluble RAGE, sRAGE）を生み出す手法に焦点を当てた。薬剤・化合物ライブラリースクリーニングと検証実験から、複数の候補化合物を同定することに成功し、今後は糖尿病血管障害の新規治療法として臨床への応用が期待された。","subitem_description_type":"Abstract"},{"subitem_description":"Receptor for advanced glycation end-products (RAGE) is considered linked to the onset and progression of diabetic vascular complications and atherosclerosis. By focusing on target therapies against RAGE, one potentially useful strategy is the conversion of the membrane-bound form of RAGE (mRAGE) to soluble isoform (sRAGE). The ectodomain shedding can increase the sRAGE level and concomitantly decrease mRAGE expression, potentially leading to the prevention and the attenuation of the diabetic vascular diseases. In this study, we screened drug and chemical libraries and identified useful candidates to mediate the ectodomain shedding of RAGE. Our finding will provide promising drugs for treating diabetic patients.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24590375, 研究期間(年度):2012-04-01 - 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「パターン認識受容体の切断により糖尿病血管合併症を制御する」課題番号24590375\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24590375/24590375seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051786","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20313637"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20313637","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24590375/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24590375/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24590375/24590375seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24590375/24590375seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-26"}],"displaytype":"detail","filename":"ME-PR-YAMAMOTO-Y-kaken 2015-6p.pdf","filesize":[{"value":"230.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-YAMAMOTO-Y-kaken 2015-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45449/files/ME-PR-YAMAMOTO-Y-kaken 2015-6p.pdf"},"version_id":"a0a632fd-d937-411e-a31e-e522c2dc1041"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"パターン認識受容体の切断により糖尿病血管合併症を制御する","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"パターン認識受容体の切断により糖尿病血管合併症を制御する"},{"subitem_title":"A strategy of RAGE shedding is promising for conquering diabetic vascular complications","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-26"},"publish_date":"2018-07-26","publish_status":"0","recid":"45449","relation_version_is_last":true,"title":["パターン認識受容体の切断により糖尿病血管合併症を制御する"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:37:41.628760+00:00"}