{"created":"2023-07-27T06:51:51.682714+00:00","id":45451,"links":{},"metadata":{"_buckets":{"deposit":"46f11f67-d7f4-42e9-ae29-6d1ffbe2cb19"},"_deposit":{"created_by":18,"id":"45451","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45451"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045451","sets":["2812:2813:2820"]},"author_link":["78964","22712"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-21","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2012-04-01 - 2014-03-31","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 研究活動スタート支援 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"遺伝子改編酵素群AID/APOBECファミリーのヒトB型肝炎ウイルス(HBV) のcovalently-closed-circular DNA (cccDNA) に対するDNA脱メチル化活性の検討を目的とした。Duck Hepatitis B Virus(DHBV)遺伝子を安定的に発現するニワトリ肝細胞株を代替モデルに用いて検討した結果、APOBEC3GがcccDNAのpreC領域のメチル化を抑制する可能性が示唆された。\n同じく環状ゲノムを持つヒトパピローマウイルス(HPV)についてもHPV16陽性子宮頸部上皮細胞株を用いて検討し、同様の可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"We aimed to verify whether AID/APOBEC family could demethylate covalently-closed-circular DNA (cccDNA) of human Hepatitis B Virus (HBV). As an alternative experimental system, we utilized chicken hepatocyte cell line that stably express duck Hepatitis B Virus (DHBV) gene. The result suggested that APOBEC3G demethylate pre-core region of DHBV cccDNA.\nWe applied the hypothesis to Human Papilloma Viruses (HPVs), that possess circular double-strand DNA. This was supported by the experiment using a HPV16-positive cervical cell line.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24890075, 研究期間(年度):2012-04-01 - 2014-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「脱メチル化酵素AIDによる慢性ウイルス感染再活性化の検討」課題番号24890075\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24890075/24890075seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051788","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70638303"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70638303","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24890075/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24890075/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24890075/24890075seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24890075/24890075seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-23"}],"displaytype":"detail","filename":"ME-PR-WAKAE-K-kaken 2014-4p.pdf","filesize":[{"value":"252.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-WAKAE-K-kaken 2014-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45451/files/ME-PR-WAKAE-K-kaken 2014-4p.pdf"},"version_id":"bfd13a0b-11d7-43a7-86dc-a4870ee2d23b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"脱メチル化酵素AIDによる慢性ウイルス感染再活性化の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脱メチル化酵素AIDによる慢性ウイルス感染再活性化の検討"},{"subitem_title":"Role of AID as a demethylating enzymes in reactivation of chronic viral hepatits","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-23"},"publish_date":"2018-07-23","publish_status":"0","recid":"45451","relation_version_is_last":true,"title":["脱メチル化酵素AIDによる慢性ウイルス感染再活性化の検討"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:18:13.235589+00:00"}