{"created":"2023-07-27T06:51:52.563588+00:00","id":45474,"links":{},"metadata":{"_buckets":{"deposit":"135f4ad6-0fdd-4bea-9d13-1e8db4498d55"},"_deposit":{"created_by":18,"id":"45474","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45474"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045474","sets":["2812:2813:2817"]},"author_link":["78992","78991"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-29","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2014-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、ベトナムのヒト免疫不全ウイルス（HIV）感染小児において、抗HIV療法(ART)が小児の免疫活性化、Th1/Th2/Th17/Tregのバランスに及ぼす影響を横断的並びに経時的に調べた。\n横断的調査では、ART導入後、CD4細胞数、Th2/Th17/Treg細胞数、およびCD4/CD8比は徐々に上昇し、正常化までに4.8-8.3年を要したが、Th17細胞数とCD8細胞の活性化状態は1年以内に正常化した。経時的調査でARTによる早期（１年以内）のTh1細胞数とCD8細胞活性化状態の正常化が確認された。また、CD4/CD8比はARTモニタリングに有用なマーカーであることが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"This study aimed to investigate the impact of ART on the immune status of HIV-infected Vietnamese children. The peripheral CD4 cells, their subsets Th1/Th2/Th17/Treg, and CD8 cell activation were analyzed cross-sectionally and longitudinally.\nCross-sectional study revealed that after ART initiation, the total CD4 cell and Th2/Th17/Treg subset counts and the CD4/CD8 ratio gradually increased, with estimated ART periods of normalization being 4.8-8.3 years, whereas Th1 counts and the CD8 cell activation status normalized within 1 year of ART. Longitudinal study confirmed the rapid Th1 recovery and early CD8 cell activation normalization after ART initiation. The CD4/CD8 ratio could be an additional marker for ART monitoring.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26461572, 研究期間(年度):2014-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「小児の抗HIV治療による免疫状態の改善と至適マーカーの同定」研究成果報告書　課題番号26461572\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26461572/26461572seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051811","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50565413"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50565413","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26461572/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26461572/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26461572/26461572seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26461572/26461572seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-26"}],"displaytype":"detail","filename":"ME-PR-BI-X-kaken 2017-6p.pdf","filesize":[{"value":"219.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-BI-X-kaken 2017-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45474/files/ME-PR-BI-X-kaken 2017-6p.pdf"},"version_id":"64772420-e6cf-4ca9-b669-6cbfc3c88cd9"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"小児の抗HIV治療による免疫状態の改善と至適マーカーの同定","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"小児の抗HIV治療による免疫状態の改善と至適マーカーの同定"},{"subitem_title":"Immune improvement after anti-retroviral therapy (ART) initiation and identification of appropriate markers for ART monitoring in HIV-infected children","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-26"},"publish_date":"2018-07-26","publish_status":"0","recid":"45474","relation_version_is_last":true,"title":["小児の抗HIV治療による免疫状態の改善と至適マーカーの同定"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:25:28.394497+00:00"}