{"created":"2023-07-27T06:51:52.740197+00:00","id":45478,"links":{},"metadata":{"_buckets":{"deposit":"bf973bfa-c190-4ebb-91b5-d2fba3630ff6"},"_deposit":{"created_by":18,"id":"45478","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45478"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045478","sets":["2812:2813:2824"]},"author_link":["78994","24020"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2008-2009","bibliographic_titles":[{"bibliographic_title":"平成21(2009)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2009 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"覚醒剤の少量反復投与により、神経細胞障害や酸化ストレスといった覚醒剤の多量投与により引き起こされる反応の有意な変化が観察されず、小胞体ストレスのマーカーであるGRP78(抗KDEL抗体)が有意に増加するこれまでの覚醒剤投与モデル動物とは異なる病態を示す実験動物モデルを作成した。\nこのモデル動物を解析することにより、覚醒剤濫用における病態解明に有用な情報を得ることが出来ると考えられ、現在解析中である。","subitem_description_type":"Abstract"},{"subitem_description":"This study examined the effect of repeated administration of methamphetamine (METH) on endoplasmic reticulum stress (ERS) in the dopaminergic neurons of rats. Lower doses of METH (0.5 and 1.0 mg/kg/day for 5d) increased GRP78 (KDEL), one of ERS markers, although superoxide dismutase-1, but no GRP78, was increased at higher doses (5 and 10 mg/kg/day for 5d). Further studies on ERS in METH-treated rats could contribute the understanding of the pathophysiology of METH-induced neuronal damages.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:20790466, 研究期間(年度):2008-2009","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「神経細胞障害と細胞ストレスに着目した覚醒剤少量投与による実験動物モデルの解析」課題番号20790466\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20790466/20790466seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051815","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=90460360"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=90460360","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790466/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790466/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20790466/20790466seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20790466/20790466seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-26"}],"displaytype":"detail","filename":"ME-PR-TAKEICHI-T-kaken 2010-4p.pdf","filesize":[{"value":"326.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-TAKEICHI-T-kaken 2010-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45478/files/ME-PR-TAKEICHI-T-kaken 2010-4p.pdf"},"version_id":"0bdd1e72-ac10-4a20-bb8b-27c0ab297b66"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"神経細胞障害と細胞ストレスに着目した覚醒剤少量投与による実験動物モデルの解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"神経細胞障害と細胞ストレスに着目した覚醒剤少量投与による実験動物モデルの解析"},{"subitem_title":"Neuron damages and cellular stress in last treated with low dose methamphetamine-treated rats","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2824"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-26"},"publish_date":"2018-07-26","publish_status":"0","recid":"45478","relation_version_is_last":true,"title":["神経細胞障害と細胞ストレスに着目した覚醒剤少量投与による実験動物モデルの解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:14:56.553381+00:00"}