{"created":"2023-07-27T06:51:52.828211+00:00","id":45480,"links":{},"metadata":{"_buckets":{"deposit":"12d4ee49-4760-4668-9f70-02fcbfc37a81"},"_deposit":{"created_by":18,"id":"45480","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45480"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045480","sets":["2812:2813:2820"]},"author_link":["79000","476"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2011-2013","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"平成23～25年度に行った100例以上の法医解剖事例について、大動脈、頸動脈、脳動脈さらに脈絡叢の組織材料、血清及び脳脊髄液のゼラチナーゼ分解活性の検討を行った。身元不明で開始して後に身元が判明した司法解剖事例から、大動脈及び冠動脈のびまん性内膜肥厚及び組織内ゼラチン分解活性が年齢推定に有効であることが分かった。血管壁組織脆弱性の視点から、血管病変の危険因子である高血圧をもたらす、未検査の続発性アルドステロン症の頻度を組織学的に調べ、充分注意が払われていないことに対して警鐘を鳴らした。動物実験では、血管のびまん性内膜肥厚は線維化の一種であるという考えから自己免疫疾患モデルマウスの解析を行った。","subitem_description_type":"Abstract"},{"subitem_description":"With regard to more than 100 cases subjected to forensic autopsy between 2011-2013, gelatinase degrading activity was investigated in aorta, carotid and cerebral arteries and choroid plexus tissue samples in addition to serum and cerebrospinal fluid. In forensic autopsies of initially unidentified cases in which subsequently identity was established, aorta and coronary artery diffuse intimal thickening and tissue gelatinolytic activity were found to be useful in the determination of age. From the viewpoint of vascular wall tissue fragility, we histologically investigated the frequency of unexamined secondary aldosteronism, a cause of hypertension and recognized risk factor for vascular lesions, and based on our findings raised an alarm that sufficient attention is not being paid to this important issue. In animal experiments, based on the contention that vascular diffuse intimal thickening represents one type of fibrosis, analysis using an autoimmune disease model mouse was conducted.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23590844, 研究期間(年度):2011-2013","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「ヒト血管壁における組織脆弱性評価の研究」課題番号23590844\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23590844/23590844seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051817","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00272956"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00272956","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590844/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590844/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23590844/23590844seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23590844/23590844seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-27"}],"displaytype":"detail","filename":"ME-PR-ZUKA-M-kaken 2014-4p.pdf","filesize":[{"value":"283.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-ZUKA-M-kaken 2014-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45480/files/ME-PR-ZUKA-M-kaken 2014-4p.pdf"},"version_id":"07657501-bb8c-4345-9c9a-435b16870a63"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ヒト血管壁における組織脆弱性評価の研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト血管壁における組織脆弱性評価の研究"},{"subitem_title":"Evaluation of human vascular wall tissue fragility","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-27"},"publish_date":"2018-07-27","publish_status":"0","recid":"45480","relation_version_is_last":true,"title":["ヒト血管壁における組織脆弱性評価の研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:18:09.412236+00:00"}