{"created":"2023-07-27T06:51:52.916385+00:00","id":45482,"links":{},"metadata":{"_buckets":{"deposit":"94e154c1-75e7-4f4b-b68e-1b9215bc5e27"},"_deposit":{"created_by":18,"id":"45482","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45482"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045482","sets":["2812:2813:2820"]},"author_link":["2482","24080"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-06-11","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2011-2013","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"精子形成不全を呈する男性不妊症（非閉塞性無精子症）のリスク遺伝子候補であるART3（ADP-ribosyltransferase 3）につき、（１）網羅的発現解析から、ART3と相互作用するタンパク質を複数見いだした。その中には精巣特異的に発現し、精子形成に関わることが知られている遺伝子が含まれ、機能的に有望な相互作用候補を得た。（２）統計遺伝学的解析から、非閉塞性無精子症に関与する新規リスク遺伝子座を複数見いだした。このうちの1つの遺伝子座に位置する遺伝子ファミリーと、ART3とが分子相互作用することを見いだしており、ART3を介した造精機能制御機構を理解する上での有望な候補遺伝子を得た。","subitem_description_type":"Abstract"},{"subitem_description":"ART3 (ADP-ribosyltransferase 3) have been identified as a susceptibility gene for non-obstructive azoospermia (NOA) in humans. The objective of this study was to reveal a molecular and genetic basis for further understanding of pathophysiological roles of testicular ART3 involved in male infertility. (1) A proteomic analysis indicated that ART3 directly interacted with various proteins, some of which were expressed in human testes, and involved in spermatogenesis. (2) Case-control genetic association studies in Japanese populations demonstrated three NOA susceptibility loci, one of which contained a family gene of the ART3-interacting proteins. Thought the proteomic and genetic analyses, we identified promising candidate genes which might have roles in ART3-dependent regulation of spermatogenesis in humans.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23510242, 研究期間(年度):2011-2013","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「特発性男性不妊症における精巣モノADPリボシル化システムの役割」課題番号23510242\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23510242/23510242seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051819","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系 / 徳島大学"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10396864"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10396864","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23510242/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23510242/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23510242/23510242seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23510242/23510242seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-27"}],"displaytype":"detail","filename":"ME-PR-TAJIMA-A-kaken 2014-4p.pdf","filesize":[{"value":"272.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-TAJIMA-A-kaken 2014-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45482/files/ME-PR-TAJIMA-A-kaken 2014-4p.pdf"},"version_id":"366fbb50-f420-40f5-b3cf-16529299d240"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"特発性男性不妊症における精巣モノADPリボシル化システムの役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"特発性男性不妊症における精巣モノADPリボシル化システムの役割"},{"subitem_title":"The role of testicular mono-ADP-ribosylation in men with idiopathic infertility","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-27"},"publish_date":"2018-07-27","publish_status":"0","recid":"45482","relation_version_is_last":true,"title":["特発性男性不妊症における精巣モノADPリボシル化システムの役割"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:18:07.696530+00:00"}