{"created":"2023-07-27T06:51:53.005242+00:00","id":45484,"links":{},"metadata":{"_buckets":{"deposit":"94cbf8da-233e-4240-9be9-b5f1247df568"},"_deposit":{"created_by":18,"id":"45484","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45484"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045484","sets":["2812:2813:2816"]},"author_link":["568","45834"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-25","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2015-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ブロッコリースプラウトに含まれる機能性因子グルコラファニンを混ぜた高脂肪食を与えたマウスは体重増加率が約15％抑えられ，内臓脂肪量が約20％減少し，脂肪肝と血糖値の上昇が抑えられた。その作用機序として，グルコラファニンが，①脱共役タンパク質１（UCP-1）を増加させ，エネルギー消費の増加と脂肪燃焼をもたらすBrowningを促進した。また，②グルコラファニンは，内毒素（LPS）を過剰産生するデスルフォビブリオ科の腸内細菌の増殖を抑制しており，血液中の内毒素を低下させ，代謝性エンドトキシン血症を改善するという作用を発見した。さらに，グルコラファニンの標的分子として転写因子Nrf2が重要であった。","subitem_description_type":"Abstract"},{"subitem_description":"Glucoraphanin, a phytochemical in broccoli sprouts, attenuated weight gain, decreased hepatic steatosis, and improved glucose tolerance and insulin sensitivity in high fat diet (HFD)-fed wild-type mice but not in HFD-fed Nrf2 knockout mice. Glucoraphanin increased uncoupling protein-1 (Ucp-1) protein levels in subcutaneous adipose depots, thereby increased energy expenditure. In addition, glucoraphanin suppressed Desulfovibrionaceae in gut microbiomes of HFD-fed mice, and decreased plasma lipopolysaccharide levels. By promoting fat browning, limiting metabolic\nendotoxemia-related chronic inflammation, and modulating\nredox stress, glucoraphanin may mitigate obesity, insulin resistance, and nonalcoholic fatty liver disease.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K00813, 研究期間(年度):2015-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「ブロッコリースプラウト抽出物による炎症制御及びエネルギー代謝調節機構の解明」課題番号15K00813\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K00813/15K00813seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051821","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70456408"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70456408","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K00813/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K00813/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K00813/15K00813seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K00813/15K00813seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-22"}],"displaytype":"detail","filename":"ME-PR-NAGATA-N-kaken 2018-5p.pdf","filesize":[{"value":"570.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NAGATA-N-kaken 2018-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45484/files/ME-PR-NAGATA-N-kaken 2018-5p.pdf"},"version_id":"91861303-a86c-40bf-8bbc-388170315acc"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ブロッコリースプラウト抽出物による炎症制御及びエネルギー代謝調節機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ブロッコリースプラウト抽出物による炎症制御及びエネルギー代謝調節機構の解明"},{"subitem_title":"Regulation of inflammation and energy metabolism by broccoli sprout extract","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-22"},"publish_date":"2019-04-22","publish_status":"0","recid":"45484","relation_version_is_last":true,"title":["ブロッコリースプラウト抽出物による炎症制御及びエネルギー代謝調節機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:58:35.505500+00:00"}