{"created":"2023-07-27T06:51:53.049120+00:00","id":45485,"links":{},"metadata":{"_buckets":{"deposit":"709b0c59-423f-4403-a681-64f9e2969868"},"_deposit":{"created_by":18,"id":"45485","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"45485"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00045485","sets":["2812:2813:2819"]},"author_link":["568","45834"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-26","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2013-04-01 - 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"近年、高脂肪食や運動習慣の欠如を背景として、脂肪肝炎（NASH）が急増している。本研究の目的は、過栄養状態の肝臓において発現が亢進するSrc homology phosphatase 2 (Shp2)が肝臓の脂肪蓄積と炎症の誘導・維持をいかに制御しているかを明らかにすることである。\n本研究によって、１）肝臓特異的Shp2欠損マウスは、特殊飼料による肝臓への脂肪蓄積と炎症を著明に抑制した。２）Shp2阻害剤の投与は特殊飼料による脂肪肝炎を部分的にではあるが改善することが明らかとなった。従って、Shp2が脂肪肝炎の新しい治療標的分子となりうる所見が得られたと考える。","subitem_description_type":"Abstract"},{"subitem_description":"Recently, non-alcoholic steatohepatitis has been rapidly increasing due to a high-fat diet and/or lack of exercise. Aim of this study is to investigate the role of Src homology phosphatase 2 (Shp2) in regulation of lipid metabolism and inflammation in the liver of mice model of NASH.\nThis study revealed that liver-specific deficiency of Shp2 reduced lipid accumulation and inflammation in the liver of mice fed CDAA diet. I also found that Shp2 inhibitor partially improved CDAA diet-induced NASH. Taken together, Shp2 might be a novel molecular target of NASH.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25860526, 研究期間(年度):2013-04-01 - 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「タンパク質チロシンフォスファターゼShp2による炎症制御機構の解明」課題番号25860526\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25860526/25860526seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00051822","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70456408"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70456408","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25860526/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25860526/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25860526/25860526seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25860526/25860526seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-27"}],"displaytype":"detail","filename":"ME-PR-NAGATA-N-kaken 2015-4p.pdf","filesize":[{"value":"218.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NAGATA-N-kaken 2015-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/45485/files/ME-PR-NAGATA-N-kaken 2015-4p.pdf"},"version_id":"156c56d9-c8d1-42fa-abb2-915a122fc87f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"タンパク質チロシンフォスファターゼShp2による炎症制御機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"タンパク質チロシンフォスファターゼShp2による炎症制御機構の解明"},{"subitem_title":"Impacts of protein tyrosine phosphatase Shp2 on liver inflammation","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-27"},"publish_date":"2018-07-27","publish_status":"0","recid":"45485","relation_version_is_last":true,"title":["タンパク質チロシンフォスファターゼShp2による炎症制御機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:37:36.710027+00:00"}