{"created":"2023-07-27T06:52:16.271402+00:00","id":46077,"links":{},"metadata":{"_buckets":{"deposit":"9640473c-28f7-45ac-9a10-dc143cf9d68a"},"_deposit":{"created_by":18,"id":"46077","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"46077"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00046077","sets":["2812:2813:2818"]},"author_link":["247","79935"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2013-04-01 - 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"近年，細胞核内では転写マシナリーが活性化している領域と不活性化している領域とが存在し，遺伝子が適切な場所に配置されることで，発現が制御されることが明らかになっているが，実際にどのような分子が染色体ゲノムの核内配置や相互作用に関わり，遺伝子発現を制御しているのか，明らかにされていない。そこで，我々はプラダーウィリ症候群やアンジェルマン症候群の発症に寄与する15q11-q13領域に着目し，15q11-q13領域の遺伝子発現やクロマチンを制御する分子の同定を試みた。その結果，15q11-q13領域のクロマチン動態を司る分子として，メチル化CpG結合タンパク質の可能性が強く示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"The PWS/AS imprinted gene cluster on human chromosome 15q11-q13 spans ~4Mb region that includes several protein-coding genes and the 450kb long UBE3A-ATS lncRNA. UBE3A-ATS is expressed from its unmethylated CpG island promoter contained in the defined ICR on the paternal chromosome. Despite the fact that PWS-IC is known to be necessary for the coordinately controlled gene expression of 15q11-q13 imprinted domain, the mechanism by which it act and how it influence to the several protein-coding genes over long distance, is unknown. In order to define the precise long-range gene regulation of 15q11-q13, we examined shRNA-based knockdown experiments by using the human/mouse hybrid cells which is containing a single human chromosome of identified parental origin. Our results support the idea that Methyl-CpG binding proteinsuch as MeCP2, Mbd1 have an essential role for long-range gene regulation of 15q11-q13.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25430167, 研究期間(年度):2013-04-01 - 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「神経細胞特異的なクロマチンダイナミクスを司る分子の同定」課題番号:25430167\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25430167/25430167seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学学際科学実験センター","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00052411","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40448311"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40448311","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25430167/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25430167/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25430167/25430167seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25430167/25430167seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-10-12"}],"displaytype":"detail","filename":"FR-PR-HORIIKE-S-kaken 2016-5p.pdf","filesize":[{"value":"175.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"FR-PR-HORIIKE-S-kaken 2016-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/46077/files/FR-PR-HORIIKE-S-kaken 2016-5p.pdf"},"version_id":"eefe1f9e-bfdd-4a90-9880-ce1b2d74eaaa"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"神経細胞特異的なクロマチンダイナミクスを司る分子の同定","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"神経細胞特異的なクロマチンダイナミクスを司る分子の同定"},{"subitem_title":"Identification of chromatic factor which is associated with neuron specific chromatin dynamics","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-10-12"},"publish_date":"2018-10-12","publish_status":"0","recid":"46077","relation_version_is_last":true,"title":["神経細胞特異的なクロマチンダイナミクスを司る分子の同定"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:47:52.563125+00:00"}