{"created":"2023-07-27T06:52:18.361659+00:00","id":46136,"links":{},"metadata":{"_buckets":{"deposit":"e0685f96-7c0d-46fd-939d-bafb36921c2a"},"_deposit":{"created_by":18,"id":"46136","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"46136"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00046136","sets":["2812:2813:2816"]},"author_link":["80007","80006"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-30","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2015-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では独自に開発した手法を用いて、配列依存的アレル特異的ヒドロキシメチル化がマウスゲノム上でどの程度普遍的に存在するかを調べることを目的とした。\n互いに亜種関係にあり多くの多型を有するJF1マウスとB6マウスを相互に掛け合わせたJF1/B6マウスとB6/JF1マウスの脳由来ゲノムを用いて、既知の配列依存的アレル特異的メチル化領域10個が配列依存的アレル特異的ヒドロキシメチル化を受けているかを\n独自に構築した方法法とバイサルファイトシークエンス法により調べた。結果として、このうち一つが配列依存的アレル特異的ヒドロキシメチル化を受けていることがわかった。","subitem_description_type":"Abstract"},{"subitem_description":"The research representative previously reported sequence-dependentallele-specific methylation. This enabled us to interpret the mechanisms for differences of various disease susceptibility caused by the sequence polymorphisms. On the other hand, genomic hydroxymethylation plays an important role in the demethylation process. Furthermore, it is suggested that genomic hydroxymethylation is also involved in regulation of gene expression. In this study, we examined whether 10 sequence-dependent allele-specific methylated regions in mice are subject to a sequence-dependentallele-specific hydroxymethylation. As a result, it was shown that one of the ten was subject to a sequence-dependent allele-specific hydroxymethylation.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K06894, 研究期間(年度):2015-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「配列依存的アレル特異的ヒドロキシメチル化の普遍性の検証」課題番号15K06894\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K06894/15K06894seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学理工研究域生命理工学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00052470","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30377402"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30377402","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K06894/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K06894/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K06894/15K06894seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K06894/15K06894seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-22"}],"displaytype":"detail","filename":"TE-PR-YAMADA-Y-kaken 2018-4p.pdf","filesize":[{"value":"87.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"TE-PR-YAMADA-Y-kaken 2018-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/46136/files/TE-PR-YAMADA-Y-kaken 2018-4p.pdf"},"version_id":"365afa19-fb6a-4d28-9ea1-6fc5c54c17d5"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"配列依存的アレル特異的ヒドロキシメチル化の普遍性の検証","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"配列依存的アレル特異的ヒドロキシメチル化の普遍性の検証"},{"subitem_title":"Is sequence-dependent allele-specific hydroxymethylation ubiquitous in the mammalian genome?","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-22"},"publish_date":"2019-04-22","publish_status":"0","recid":"46136","relation_version_is_last":true,"title":["配列依存的アレル特異的ヒドロキシメチル化の普遍性の検証"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:56:25.447226+00:00"}