{"created":"2023-07-27T06:52:18.405817+00:00","id":46137,"links":{},"metadata":{"_buckets":{"deposit":"d4f99fc3-38b6-4456-a35f-9f41d230ca05"},"_deposit":{"created_by":18,"id":"46137","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"46137"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00046137","sets":["2812:2813:2819"]},"author_link":["80007","80006"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-06-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2012-04-01 - 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究代表者は、配列依存的アレル特異的メチル化の存在を世界に先駆けて報告し、多型配列が引き起こす各種疾患感受性差異の作用機序をゲノムメチル化の有無が導く遺伝子発現差異を通して理解可能なことを示した。一方、近年ヒドロキシメチル化がゲノム上からの脱メチル化過程で重要な役割を担っていることや、遺伝子発現調節にも関与していることが示唆されている。そこで本研究では、マウスの6個の既知の配列依存的アレル特異的メチル化領域が配列依存的アレル特異的ヒドロキシメチル化を受けているか否かを調べた。結果としてこのうちの一つが配列依存的アレル特異的ヒドロキシメチル化を受けていることが示された。","subitem_description_type":"Abstract"},{"subitem_description":"The research representative previously reported a sequence-dependent allele-specific methylation. This enabled us to interpret the mechanism of various disease susceptibility caused by sequence polymorphisms through gene expression differences caused by the presence or absence of genomic methylation at a polymorphic site. On the other hand, genomic hydroxymethylation plays an important role in the demethylation process. Furthermore, it is suggested that genomic hydroxymethylation is also involved in gene expression regulation. In this study, we examined whether the six known sequence-dependent allele-specific methylation regions in mouse are subject to a sequence-dependent allele-specific hydroxymethylation. As a result, it was shown that one of the six was subject to a sequence-dependent allele-specific hydroxymethylation.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24510266, 研究期間(年度):2012-04-01 - 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「配列依存的アレル特異的ヒドロキシメチル化の探索」研究成果報告書　課題番号24510266\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24510266/24510266seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学理工研究域生命理工学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00052471","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30377402"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30377402","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24510266/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24510266/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24510266/24510266seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24510266/24510266seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-10-15"}],"displaytype":"detail","filename":"TE-PR-YAMADA-Y-kaken 2015-4p.pdf","filesize":[{"value":"88.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"TE-PR-YAMADA-Y-kaken 2015-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/46137/files/TE-PR-YAMADA-Y-kaken 2015-4p.pdf"},"version_id":"39bcdc73-db83-4632-a129-2c45159cd892"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"配列依存的アレル特異的ヒドロキシメチル化の探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"配列依存的アレル特異的ヒドロキシメチル化の探索"},{"subitem_title":"Search for sequence-dependent allele-specific hydroxymethylation","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-10-15"},"publish_date":"2018-10-15","publish_status":"0","recid":"46137","relation_version_is_last":true,"title":["配列依存的アレル特異的ヒドロキシメチル化の探索"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:35:45.917681+00:00"}