{"created":"2023-07-27T06:52:19.837195+00:00","id":46181,"links":{},"metadata":{"_buckets":{"deposit":"18251d7f-3a03-45a3-bd2f-2c096f5a3964"},"_deposit":{"created_by":18,"id":"46181","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"46181"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00046181","sets":["2812:2813:2816"]},"author_link":["80056","176"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-29","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2015-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々は基質（ポリフェノール）によってミトコンドリアの生合成が誘発されること、とりわけ、運動が引き起こす効果を増幅させることを発見した。この事象はポリフェノール依存的に活性化するシグナル経路の存在を推測させるものの、体系的な研究が進んでいない。本研究では、運動トレーニングやクルクミン投与によって生じる骨格筋のミトコンドリア生合成の分子機序とミトコンドリアの呼吸機能を明らかにすることを目的とした。本研究の結果、継続的な運動トレーニングはそれ自体がミトコンドリア生合成を促進する刺激ではあるが、クルクミン投与によっても運動とは別にミトコンドリア生合成を上昇させることが明らかになった。","subitem_description_type":"Abstract"},{"subitem_description":"Mitochondrial biogenesis in response to exercise is reliant on adaptive changes through potentially key signal for activating mitochondrial biogenesis (eg. activation of SIRT1, AMPK and PGC-1a). Polyphenol curcumin is a natural antioxidant exhibiting a variety of pharmacological activities and therapeutic properties. However, it remains unknown the effect of curcumin and underlying mechanism on skeletal muscle for regulation of mitochondrial biogenesis. The purpose of the present study was to examine the effects of endurance training (eTR) and curcumin treatment on mitochondrial biogenesis and to identify some of key cascade along the cell signaling. The experimental results suggested that that curcumin treatment with eTR regulated mitochondria biogenesis in skeletal muscle through SIRT1 and AMPK -mediated signaling pathway.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K12666, 研究期間(年度):2015-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「基質による骨格筋ミトコンドリア生合成の新たな分子機序の解明と呼吸機能評価の確立」課題番号15K12666\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K12666/15K12666seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学人間社会研究域人間科学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00052515","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50323283"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50323283","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K12666/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K12666/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K12666/15K12666seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K12666/15K12666seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-25"}],"displaytype":"detail","filename":"ED-PR-MASUDA-K-kaken 2018-4p.pdf","filesize":[{"value":"931.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ED-PR-MASUDA-K-kaken 2018-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/46181/files/ED-PR-MASUDA-K-kaken 2018-4p.pdf"},"version_id":"5ef5d86a-c31a-47a9-ae5e-96fdb1b7da1e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"基質による骨格筋ミトコンドリア生合成の新たな分子機序の解明と呼吸機能評価の確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"基質による骨格筋ミトコンドリア生合成の新たな分子機序の解明と呼吸機能評価の確立"},{"subitem_title":"New mechanism of mitochondrial biogenesis mediated by nutritinal substrate in skeletal muscle","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-25"},"publish_date":"2019-04-25","publish_status":"0","recid":"46181","relation_version_is_last":true,"title":["基質による骨格筋ミトコンドリア生合成の新たな分子機序の解明と呼吸機能評価の確立"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:49:09.912967+00:00"}