{"created":"2023-07-27T06:52:20.102517+00:00","id":46187,"links":{},"metadata":{"_buckets":{"deposit":"5e18890e-b3ed-416b-a9d7-4ac18623583d"},"_deposit":{"created_by":18,"id":"46187","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"46187"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00046187","sets":["2812:2813:2816"]},"author_link":["2327","80063"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-06-27","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2015-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"生体膜は凹凸形状を持っており、形状に依存した脂質やタンパク質が特異的に離合集散することで、生命現象の素過程が実現されている。本研究では、この素過程を高速AFMでリアルタイム観察するために、集積イオンビーム（FIB）法やナノ粒子インプリンティングを用いて、ガラス基板上やPDMS上にサブマイクロメートルオーダーの細孔を持った新規のAFM観察基板を開発した。開発した基板を応用して、膜形状に依存した脂質分子の拡散運動や膜結合タンパク質の集合様式、サスペンドした天然膜を観察することに成功した。","subitem_description_type":"Abstract"},{"subitem_description":"Biological membranes have uneven physical shapes. By recognizing on the physical shapes, lipids and proteins specifically assemble and disassemble, and realize their sophisticated functions. In this research project, to realize the real-time observations of these biological processes by high-speed AFM, new AFM substrates with sub-micrometer sized holes have been developed on a glass and PDMS surfaces using Focused Ion Beam (FIB) lithography and nanosphere imprinting. Using the AFM substrates developed here, some phenomena and objects depending on the physical shapes of membrane, diffusion of lipid molecules, assembling of a membrane protein as well as a suspended native membrane, were directly visualized.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15H04360, 研究期間(年度):2015-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「高速AFMによる生体膜の形状に依存したタンパク質の離合集散メカニズムの解明」課題番号15H04360\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15H04360/15H04360seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学新学術創成研究機構ナノ生命科学研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00052521","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30584635"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30584635","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04360/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04360/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15H04360/15H04360seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15H04360/15H04360seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-26"}],"displaytype":"detail","filename":"SC-PR-KODERA-N-kaken 2018-6p.pdf","filesize":[{"value":"491.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"SC-PR-KODERA-N-kaken 2018-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/46187/files/SC-PR-KODERA-N-kaken 2018-6p.pdf"},"version_id":"7e5b3221-5c0a-47a1-8e87-6e0cd111d2aa"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"高速AFMによる生体膜の形状に依存したタンパク質の離合集散メカニズムの解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"高速AFMによる生体膜の形状に依存したタンパク質の離合集散メカニズムの解明"},{"subitem_title":"Study of protein-assemble/disassemble on biological membrane depending on the membrane shape by high-speed AFM","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-26"},"publish_date":"2019-04-26","publish_status":"0","recid":"46187","relation_version_is_last":true,"title":["高速AFMによる生体膜の形状に依存したタンパク質の離合集散メカニズムの解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:48:06.898769+00:00"}