{"created":"2023-07-27T06:52:20.234525+00:00","id":46190,"links":{},"metadata":{"_buckets":{"deposit":"7370e72e-6f2e-4f7d-8848-fb276f8b6b5b"},"_deposit":{"created_by":18,"id":"46190","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"46190"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00046190","sets":["2812:2813:2816"]},"author_link":["80066","189"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-15","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2015-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究ではヒト細胞を培養しながら交流磁場を96時間まで連続曝露できるシステムを構築し，薬剤作用における交流磁場影響の曝露時間の依存性を検討した。その結果，ヒト肺がん細胞において24～96時間よりも0.5～4時間の短時間の交流磁場曝露が，非曝露群より有意に薬剤作用の増強することが明らかとなった。また，肺がん細胞だけでなく，ヒト肝がん細胞でも検討したところ，同様に交流磁場曝露による抗がん剤の作用増強が認められた。","subitem_description_type":"Abstract"},{"subitem_description":"We have constructed a magnetic fields exposure system for long-term experiments with human cells, and investigated the time dependence of magnetic fields exposure influence on drug potency. The results indicated that the potency of anticancer drug, cisplatin to human lung cancer cells was increased significantly by exposure to magnetic fields for 0.5 ~4 h, not for 24 h or more. Furthermore, our results suggested that the magnetic fields enhance the potency of anticancer drugs to not only lung cancer cells but also human hepatoma cells.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K01328, 研究期間(年度):2015-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「交流磁場によるがん標的化学療法の開発」課題番号15K01328\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K01328/15K01328seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学理工研究域生命理工学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00052524","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10359713"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10359713","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K01328/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K01328/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K01328/15K01328seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K01328/15K01328seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-26"}],"displaytype":"detail","filename":"TE-PR-KAKIKAWA-M-kaken 2018-4p.pdf","filesize":[{"value":"298.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"TE-PR-KAKIKAWA-M-kaken 2018-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/46190/files/TE-PR-KAKIKAWA-M-kaken 2018-4p.pdf"},"version_id":"42d70258-d923-4b27-8182-5ef0d1e633a8"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"交流磁場によるがん標的化学療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"交流磁場によるがん標的化学療法の開発"},{"subitem_title":"Impact evaluation of magnetic fields toward a target chemotherapy","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-26"},"publish_date":"2019-04-26","publish_status":"0","recid":"46190","relation_version_is_last":true,"title":["交流磁場によるがん標的化学療法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:48:05.333076+00:00"}