{"created":"2023-07-27T06:52:22.794262+00:00","id":46264,"links":{},"metadata":{"_buckets":{"deposit":"f197d0ba-f6ac-4dca-94f9-eead2d86ee05"},"_deposit":{"created_by":18,"id":"46264","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"46264"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00046264","sets":["2812:2813:2816"]},"author_link":["80169","80168"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-17","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2015-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、新規「放射性金属－八臭素化ポルフィリン錯体」を開発し、腫瘍イメージング剤としての可能性について検討した。その結果、八臭素化ポルフィリン誘導体の一つであるOBTCPPが、診断用核種の111Inで短時間で標識可能であった。111In-OBTCPPは、colon26細胞を移植した担癌マウスにおいて、投与24時間後、腫瘍へ約5%ID/g集積し、腫瘍/筋肉比は、10以上を示した。さらに、投与24時間後にSPECT-CT撮像を行った所、体内分布実験の結果を反映し、腫瘍を画像化可能であった。以上より、111In-OBTCPPは腫瘍イメージング剤としての可能性を有することが示された。","subitem_description_type":"Abstract"},{"subitem_description":"In this study, a new radiometal-octabromoporphyrines was developed and the possibililty of application for a new tumor imaging agent was examined. As a result, it was found that Octabromotetrakis (4-carboxyphenyl)porphine（OBTCPP） could be very rapidly radiolabelled by 111In, a radio nuclear for diagnosis. It was also found that, in tumor bearing mice transplanted colon26 tumor cell, 111In-OBTCPP was accumulated in the tumor at about 5%ID/g, and tumor to muscle ratio was over 10. Furthermore, in SPECT-CT imaging study, the image acquired 24 h after injection reflected bio-distribution study, and the tumor was visualized. In conclusion, 111In-OBTCPP has possibility of application for a new tumor imaging agent.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K09886, 研究期間(年度):2015-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「腫瘍イメージング剤としての放射性金属－八臭素化ポルフィリンの開発研究」課題番号15K09886\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K09886/15K09886seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学学際科学実験センターアイソトープ総合研究施設","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00052597","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10368483"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10368483","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K09886/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K09886/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K09886/15K09886seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K09886/15K09886seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-22"}],"displaytype":"detail","filename":"AD-PR-KITAMURA-Y-kaken 2018-5p.pdf","filesize":[{"value":"174.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"AD-PR-KITAMURA-Y-kaken 2018-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/46264/files/AD-PR-KITAMURA-Y-kaken 2018-5p.pdf"},"version_id":"5ce6fb6f-f2c4-4c1e-9f8b-7a7c3b2ae51f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"腫瘍イメージング剤としての放射性金属－八臭素化ポルフィリンの開発研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"腫瘍イメージング剤としての放射性金属－八臭素化ポルフィリンの開発研究"},{"subitem_title":"Study on the development of radiometal-octabromorphyrines as a tumor imaging agent","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-22"},"publish_date":"2019-04-22","publish_status":"0","recid":"46264","relation_version_is_last":true,"title":["腫瘍イメージング剤としての放射性金属－八臭素化ポルフィリンの開発研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:56:26.807818+00:00"}