{"created":"2023-07-27T06:52:22.838840+00:00","id":46265,"links":{},"metadata":{"_buckets":{"deposit":"47e4eb11-02e7-4d4b-84a8-f144121e681c"},"_deposit":{"created_by":18,"id":"46265","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"46265"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00046265","sets":["2812:2813:2819"]},"author_link":["80169","80168"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-26","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2012-04-01 - 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、新規「放射性金属－八臭素化ポルフィリン錯体」を開発し、腫瘍イメージング剤としての応用について検討した。その結果、Octabromotetrakis (4-carboxyphenyl)porphine（OBTCPP）が、診断用核種の111Inで短時間で標識可能なこと、NB2a細胞、またはKLN205細胞を移植した担癌マウスにおいて、111In-OBTCPPは投与24時間後、腫瘍へ約4% dose/gの集積を示し、腫瘍/筋肉比は、10以上を示すことを見出した。","subitem_description_type":"Abstract"},{"subitem_description":"In this study, a new radiometal-octabromoporphyrines was developed and the possibililty of application for a new tumor imaging agent was examined. As a result, it was found that Octabromotetrakis (4-carboxyphenyl)porphine（OBTCPP） could be radiolabelled by 111In, a radio nuclear for diagnosis, in short times. It was also found that, in tumor bearing mice which transplanted NB2a tumor cell or KLN205 tumor cell, 111In-OBTCPP was accumulated in both tumors at about 4% dose/g, and tumor to muscle ratio was over 10 in the tumors.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24591812, 研究期間(年度):2012-04-01 - 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「腫瘍イメージング剤としての放射性金属- 八臭素化ポルフィリンの開発と応用」研究成果報告書　課題番号24591812\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24591812/24591812seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学学際科学実験センターアイソトープ総合研究施設","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00052598","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10368483"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10368483","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24591812/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24591812/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24591812/24591812seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24591812/24591812seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-10-26"}],"displaytype":"detail","filename":"AD-PR-KITAMURA-Y-kaken 2015-6p.pdf","filesize":[{"value":"188.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"AD-PR-KITAMURA-Y-kaken 2015-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/46265/files/AD-PR-KITAMURA-Y-kaken 2015-6p.pdf"},"version_id":"79de8d02-fa04-4c39-a0b5-6e5f883fe12e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"腫瘍イメージング剤としての放射性金属- 八臭素化ポルフィリンの開発と応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"腫瘍イメージング剤としての放射性金属- 八臭素化ポルフィリンの開発と応用"},{"subitem_title":"Development and application of radiometal-octabromoporphyrin as a Tumor imaging agent","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-10-26"},"publish_date":"2018-10-26","publish_status":"0","recid":"46265","relation_version_is_last":true,"title":["腫瘍イメージング剤としての放射性金属- 八臭素化ポルフィリンの開発と応用"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:35:38.001136+00:00"}