{"created":"2023-07-27T06:52:28.119736+00:00","id":46410,"links":{},"metadata":{"_buckets":{"deposit":"71b74069-aeab-4b5f-8b9f-5d9512894b88"},"_deposit":{"created_by":18,"id":"46410","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"46410"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00046410","sets":["1132:1133:1134"]},"author_link":["80410","2972","80411","80412","80405","80414","80408","80403","80404","80406","80399","80400","80402","80401","80416","80409","80415","80413","80407"],"item_59_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"23","bibliographicPageEnd":"35118","bibliographicPageStart":"35106","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"Oncotarget"}]}]},"item_59_creator_5":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"澤田, 武"}],"nameIdentifiers":[{},{}]}]},"item_59_description_23":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To clarify the molecular and clinicopathological characteristics of colorectal serrated lesions, we assessed the DNA methylation of cancer-associated genes in a cohort of BRAF-mutant precancerous lesions from 94 individuals. We then compared those results with the lesions’ clinicopathological features, especially colorectal subsites. The lesions included hyperplastic polyps (n = 16), traditional serrated adenomas (TSAs) (n = 15), TSAs with sessile serrated adenomas (SSAs) (n = 6), SSAs (n = 49) and SSAs with dysplasia (n = 16). The prevalence of lesions exhibiting the CpG island methylator phenotype (CIMP) was lower in the sigmoid colon and rectum than in other bowel subsites, including the cecum, ascending, transverse and descending colon. In addition, several cancer-associated genes showed higher methylation levels within lesions in the proximal to sigmoid colon than in the sigmoid colon and rectum. These results indicate that the methylation status of lesions with BRAF mutation is strongly associated with their location, histological findings and neoplastic pathways. By contrast, no difference in aberrant DNA methylation was observed in normal-appearing background colonic mucosa along the bowel subsites, which may indicate the absence of an epigenetic field defect.","subitem_description_type":"Abstract"}]},"item_59_description_7":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健学総合研究科先進的地域医療研究講座 = Department of Advanced Research in Community Medicine","subitem_description_type":"Other"}]},"item_59_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00052742","subitem_identifier_reg_type":"JaLC"}]},"item_59_publisher_19":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Impact Journals"}]},"item_59_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.18632/oncotarget.9044","subitem_relation_type_select":"DOI"}}]},"item_59_relation_30":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.ncbi.nlm.nih.gov/pubmed/27145369"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.ncbi.nlm.nih.gov/pubmed/27145369","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://doi.org/10.18632/oncotarget.9044"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.18632/oncotarget.9044","subitem_relation_type_select":"DOI"}}]},"item_59_source_id_11":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1949-2553","subitem_source_identifier_type":"ISSN"}]},"item_59_version_type_27":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sawada, Takeshi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Yamamoto, Eiichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamano, Hiro-o"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nojima, Masanori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Harada, Taku"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maruyama, Reo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ashida, Masami"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Aoki, Hironori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsushita, Hiro-o"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshikawa, Kenjiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Harada, Eiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Yoshihito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wakita, Shigenori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Niinuma, Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kai, Masahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Eizuka, Makoto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sugai, Tamotsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Hiromu"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-11-09"}],"displaytype":"detail","filename":"ME-PR-SAWADA-T-35106.pdf","filesize":[{"value":"4.8 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SAWADA-T-35106.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/46410/files/ME-PR-SAWADA-T-35106.pdf"},"version_id":"05b9601b-6f7b-4d50-8876-5a7bdbb7a070"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Assessment of epigenetic alterations in early colorectal lesions containing BRAF mutations","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Assessment of epigenetic alterations in early colorectal lesions containing BRAF mutations"}]},"item_type_id":"59","owner":"18","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-11-09"},"publish_date":"2018-11-09","publish_status":"0","recid":"46410","relation_version_is_last":true,"title":["Assessment of epigenetic alterations in early colorectal lesions containing BRAF mutations"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T16:52:18.086215+00:00"}