{"created":"2023-07-27T06:52:30.690640+00:00","id":46478,"links":{},"metadata":{"_buckets":{"deposit":"d3162a72-35f3-4da7-a9d9-04fe1aa4846d"},"_deposit":{"created_by":18,"id":"46478","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"46478"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00046478","sets":["2812:2813:2817"]},"author_link":["80506","80505"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-29","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2014-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"シグマ（σ）-2受容体は，乳がんや膵がんなど多種の固形腫瘍細胞において発現が見られ，特に増殖期では静止期と比べ，最大10倍のσ-2受容体が過剰発現していることが明らかにされている.即ち，σ-2受容体は増殖期の固形腫瘍細胞の重要なバイオマーカーであり，σ-2受容体イメージングは，がんの早期発見や増殖能診断に有効な手段となる可能性を意味している.本研究において開発した[125I]PIDVは，in vitro及びin vivo において優れたσ-2受容体集積能を示し、また[123I]PIDVをヒト乳腺癌細胞MCF-7担癌マウスに投与し、SPECTによるσ-2受容体イメージングに成功した。","subitem_description_type":"Abstract"},{"subitem_description":"Expression of sigma-2 receptor is seen in many kinds of solid tumor cell, such as breast cancer and the pancreatic cancer, and sigma-2 receptor of up to 10 times overexpressed in the proliferation period. In other words, sigma-2 receptor was important biomarker of the solid tumor cell for the proliferation period, and sigma-2 receptor imaging is estimated to possess the possibility for early detection and the increase ability diagnosis of cancer. [125I]PIDV, which I developed in this study, showed superior sigma-2 receptor accumulation in in vitro and in vivo and [123I]PIDV worked successfully in sigma-2 receptor imaging with tumor-bearing mouse (human breast adenocarcinoma cell line MCF-7) by the SPECT.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26860987, 研究期間(年度):2014-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「固形腫瘍の早期発見・増殖能診断を目的としたσ-2受容体イメージング剤の開発研究」研究成果報告書　課題番号26860987\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26860987/26860987seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学学際科学実験センターアイソトープ総合研究施設","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00052810","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50579836"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50579836","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26860987/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26860987/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26860987/26860987seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26860987/26860987seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-11-16"}],"displaytype":"detail","filename":"AD-PR-KOZAKA-T-kaken 2017-5p.pdf","filesize":[{"value":"259.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"AD-PR-KOZAKA-T-kaken 2017-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/46478/files/AD-PR-KOZAKA-T-kaken 2017-5p.pdf"},"version_id":"23d0c5db-fc61-4836-be18-ab2bdfacd0da"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"固形腫瘍の早期発見・増殖能診断を目的としたσ-2受容体イメージング剤の開発研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"固形腫瘍の早期発見・増殖能診断を目的としたσ-2受容体イメージング剤の開発研究"},{"subitem_title":"Development of the sigma-2 receptor imaging agent for the purpose of early detection and the proliferation potency diagnosis of the solid tumor","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-11-16"},"publish_date":"2018-11-16","publish_status":"0","recid":"46478","relation_version_is_last":true,"title":["固形腫瘍の早期発見・増殖能診断を目的としたσ-2受容体イメージング剤の開発研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:08:36.814498+00:00"}