{"created":"2023-07-27T06:52:32.723803+00:00","id":46537,"links":{},"metadata":{"_buckets":{"deposit":"c11549c9-0b1a-4006-abbe-bea334c2af79"},"_deposit":{"created_by":18,"id":"46537","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"46537"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00046537","sets":["2812:2813:2815"]},"author_link":["2881","20436"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-05-22","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2015-04-01 - 2019-03-31","bibliographic_titles":[{"bibliographic_title":"平成30(2018)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2018 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"sJIAは発熱、関節痛などの症状を特徴とする、慢性炎症性疾患である。その原因はいまだに不明であるが、IL-18 の異常高値がその病態の中核をなすと考えられている。一方、急性炎症病態が制御不十分な場合には、MASとして知られる、重篤な多臓器傷害が惹起され、しばしば致命的な経過をたどる。したがって sJIA の診療にあたっては、これを早期に診断すると同時に、MAS 合併を予測し迅速な治療介入を行うことが必須である。本研究では、sJIA の炎症病態の指標となる種々のバイオマーカーを明らかにすると同時に、MAS 合併のリスク因子についても明らかとし、sJIA の診断・治療に大きく貢献した。","subitem_description_type":"Abstract"},{"subitem_description":"sJIA is a chronic inflammatory illness characterized by fever and join pain. Although its etiology remains unknown, extremely elevated serum level of IL-18 is a cardinal feature of the disease. When the inflammatory condition is not properly controlled, there often exists s risk of inducing macrophage activation syndrome, or MAS, which occasionally leads to fatal outcome. It is therefore very important to establish efficient system to diagnose sJIA early and predict the onset of MAS timely to start immediate therapeutic intervention. In this study, several biomarkers were found to be useful for this purpose and risk factors of MAS induction was also revealed. The whole study contributed a lot to the diagnosis and treatment of sJIA/MAS.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15H04873, 研究期間(年度):2015-04-01 - 2019-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「オミクス情報を駆使した全身型特発性関節炎分子病態の解明と先制医療開発」研究成果報告書　課題番号15H04873\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15H04873/15H04873seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00052869","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40210281"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40210281","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04873/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04873/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15H04873/15H04873seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15H04873/15H04873seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-13"}],"displaytype":"detail","filename":"ME-PR-YACHIE-A-kaken 2019-6p.pdf","filesize":[{"value":"129.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-YACHIE-A-kaken 2019-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/46537/files/ME-PR-YACHIE-A-kaken 2019-6p.pdf"},"version_id":"68f97d19-8775-4731-8a98-133ac33f43f9"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"オミクス情報を駆使した全身型特発性関節炎分子病態の解明と先制医療開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"オミクス情報を駆使した全身型特発性関節炎分子病態の解明と先制医療開発"},{"subitem_title":"Omics-based analysis of molecular pathogenesis of systemic juvenile idiopathic arthritis and development of novel therapeutic intervention","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2815"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-13"},"publish_date":"2020-04-13","publish_status":"0","recid":"46537","relation_version_is_last":true,"title":["オミクス情報を駆使した全身型特発性関節炎分子病態の解明と先制医療開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:40:49.493911+00:00"}