@article{oai:kanazawa-u.repo.nii.ac.jp:00046617,
 author = {五十嵐, 登 and Igarashi, Noboru and Takeya, Ryouhei and Sato, Tamotsu},
 journal = {Clinical Pediatric Endocrinology},
 month = {},
 note = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85024290405&doi=10.1297%2fcpe.2.Supple2_79&partnerID=40&md5=12626aca76eb2a4e78f5240390705369, Insulin-like growth factor-II (IGF-II) and its specific receptor are present in the central nervous system (CNS) of experimental animal models, where this peptide has unique roles in neuronal growth and differentiation. IGF-II in the cerebrospinal fluid (CSF), as well as in plasma, is bound to specific binding protein (IGFBP). In this study we examined CSF IGF-II levels and IGFBP patterns in children with various physiological and pathological states. IGF-II, dissociated from IGFBP by acid gel chromatography, was measured by RIA, and IGFBP analyzed by western-ligand blotting. CSF IGF- II levels were 16.7±4.9 ng/ml in control subjects and there were no age-related variations. In some cases with CNS tumor, hydrocephalus and inflammatory conditions, their CSF IGF-II levels were increased. CSF IGFBP mainly consisted of 34kd, 31kd and 24kd protein. In contrast to serum IGFBP, CSF IGFBP patterns were almost unaffected by age, and were increased in some CNS inflammatoryconditions. Although the specific role of IGF-II in the human CNS remains to be defined, our results suggest that the regulatory mechanisms for the IGF-II /IGFBP system are present in the human CNS as well as in animal models.},
 pages = {79--84},
 title = {Insulin-Like Growth Factor (Igf) - Ii and Igf-Binding Protein in Human Spinal Fluid},
 volume = {2},
 year = {1993}
}