@article{oai:kanazawa-u.repo.nii.ac.jp:00046675,
 author = {多田, 隼人 and 野村, 章洋 and 野原, 淳 and 稲津, 明広 and 馬淵, 宏 and 山岸, 正和 and 川尻, 剛照 and Tada, Hayato and Nomura, Akihiro and Nohara, Atsushi and Inazu, Akihiro and Mabuchi, Hiroshi and YAMAGISHI, Masakazu and Kawashiri, Masa-aki},
 issue = {12},
 journal = {Journal of Atherosclerosis and Thrombosis},
 month = {},
 note = {Aim: We aimed to clarify post-prandial accumulation of remnant-like particles (RLP) in patients with sitosterolemia.
\nMethods: Oral fat tolerance test cream (Jomo Shokuhin, Takasaki, Japan) 50 g was given per body surface area (m2); blood sampling was performed at 2 h intervals up to 6 h. Plasma lipoprotein fractions and RLP fractions were determined in four sitosterolemic subjects with double mutations in ATP-binding cassette (ABC) sub-family G member 5 or member 8 (ABCG5 or ABCG8) gene (mean age=18 yr, median low-density lipoprotein cholesterol [LDL-C]=154 mg/dL), six heterozygous carriers (mean age=31 yr, median LDL-C=105 mg/dL), and five subjects with heterozygous familial hypercholesterolemia (FH, mean age=32 yr, median LDL-C=221 mg/dL). The incremental area under curve (iAUC) of lipids, including LDL-C, apolipoprotein B-48 (apoB48), RLP cholesterol (RLP-C), and RLP triglyceride (RLP-TG) were evaluated.
\nResults: After oral fat load, there was no significant difference of the iAUC of LDL-C between sitosterolemia and heterozygous FH, whereas the iAUC of apoB48 was significantly larger in the sitosterolemic subjects compared with that of heterozygous FH (2.9 µg/mL×h vs. 1.3 µg/mL×h, p＜0.05). Under these conditions, the iAUCs of RLP-C and RLP-TG levels were significantly larger in the sitosterolemic subject compared with those of heterozygous FH (9.5 mg/dL×h vs. 5.7 mg/dL×h, p＜0.05; 149 mg/dL×h vs. 40 mg/dL×h, p＜0.05, respectively), whereas those of heterozygous carriers were comparable with those with heterozygous FH.
\nConclusions: Post-prandial lipoprotein metabolism in sitosterolemia appeared to be impaired, leading to their elevation in serum sterol levels. (UMIN Clinical Trials Registry number, UMIN000020330), This article distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License., 金沢大学附属病院循環器内科},
 pages = {1188--1195},
 title = {Post-prandial Remnant Lipoprotein Metabolism in Sitosterolemia},
 volume = {25},
 year = {2018}
}