{"created":"2023-07-27T06:52:37.906136+00:00","id":46675,"links":{},"metadata":{"_buckets":{"deposit":"ed3ef118-773e-44a1-9ec1-8b09058105bc"},"_deposit":{"created_by":18,"id":"46675","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"46675"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00046675","sets":["1132:1133:1134"]},"author_link":["342","69779","21335","63343","265","65635","63344","513","63330","69780","63329","539","81245","333"],"item_59_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"1195","bibliographicPageStart":"1188","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"Journal of Atherosclerosis and Thrombosis"}]}]},"item_59_creator_5":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"多田, 隼人"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"野村, 章洋"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"野原, 淳"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"稲津, 明広"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"馬淵, 宏"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"山岸, 正和"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"川尻, 剛照"}],"nameIdentifiers":[{},{},{},{}]}]},"item_59_description_23":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aim: We aimed to clarify post-prandial accumulation of remnant-like particles (RLP) in patients with sitosterolemia.\n\\nMethods: Oral fat tolerance test cream (Jomo Shokuhin, Takasaki, Japan) 50 g was given per body surface area (m2); blood sampling was performed at 2 h intervals up to 6 h. Plasma lipoprotein fractions and RLP fractions were determined in four sitosterolemic subjects with double mutations in ATP-binding cassette (ABC) sub-family G member 5 or member 8 (ABCG5 or ABCG8) gene (mean age=18 yr, median low-density lipoprotein cholesterol [LDL-C]=154 mg/dL), six heterozygous carriers (mean age=31 yr, median LDL-C=105 mg/dL), and five subjects with heterozygous familial hypercholesterolemia (FH, mean age=32 yr, median LDL-C=221 mg/dL). The incremental area under curve (iAUC) of lipids, including LDL-C, apolipoprotein B-48 (apoB48), RLP cholesterol (RLP-C), and RLP triglyceride (RLP-TG) were evaluated.\n\\nResults: After oral fat load, there was no significant difference of the iAUC of LDL-C between sitosterolemia and heterozygous FH, whereas the iAUC of apoB48 was significantly larger in the sitosterolemic subjects compared with that of heterozygous FH (2.9 µg/mL×h vs. 1.3 µg/mL×h, p＜0.05). Under these conditions, the iAUCs of RLP-C and RLP-TG levels were significantly larger in the sitosterolemic subject compared with those of heterozygous FH (9.5 mg/dL×h vs. 5.7 mg/dL×h, p＜0.05; 149 mg/dL×h vs. 40 mg/dL×h, p＜0.05, respectively), whereas those of heterozygous carriers were comparable with those with heterozygous FH.\n\\nConclusions: Post-prandial lipoprotein metabolism in sitosterolemia appeared to be impaired, leading to their elevation in serum sterol levels. (UMIN Clinical Trials Registry number, UMIN000020330)","subitem_description_type":"Abstract"}]},"item_59_description_24":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"This article distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.","subitem_description_type":"Other"}]},"item_59_description_7":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院循環器内科","subitem_description_type":"Other"}]},"item_59_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00053007","subitem_identifier_reg_type":"JaLC"}]},"item_59_publisher_19":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本動脈硬化学会 = Japan Atherosclerosis Society"}]},"item_59_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.5551/jat.44768","subitem_relation_type_select":"DOI"}}]},"item_59_relation_30":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.jstage.jst.go.jp/browse/jat/-char/ja"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jstage.jst.go.jp/browse/jat/-char/ja","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.j-athero.org/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.j-athero.org/","subitem_relation_type_select":"URI"}}]},"item_59_rights_25":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 日本動脈硬化学会 Japan Atherosclerosis Society"}]},"item_59_source_id_11":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1340-3478","subitem_source_identifier_type":"ISSN"}]},"item_59_source_id_13":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11018976","subitem_source_identifier_type":"NCID"}]},"item_59_version_type_27":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tada, Hayato"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Nomura, Akihiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Nohara, Atsushi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Inazu, Akihiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Mabuchi, Hiroshi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"YAMAGISHI, Masakazu"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kawashiri, Masa-aki"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-01-10"}],"displaytype":"detail","filename":"ME-PR-TADA-H-1188.pdf","filesize":[{"value":"790.5 kB"}],"format":"application/pdf","licensetype":"license_10","mimetype":"application/pdf","url":{"label":"ME-PR-TADA-H-1188.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/46675/files/ME-PR-TADA-H-1188.pdf"},"version_id":"cadc148e-22f6-452b-8a9c-d5b0c31421bc"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Post-prandial Remnant Lipoprotein Metabolism in Sitosterolemia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Post-prandial Remnant Lipoprotein Metabolism in Sitosterolemia"}]},"item_type_id":"59","owner":"18","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-01-10"},"publish_date":"2019-01-10","publish_status":"0","recid":"46675","relation_version_is_last":true,"title":["Post-prandial Remnant Lipoprotein Metabolism in Sitosterolemia"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T16:41:45.531076+00:00"}