{"created":"2023-07-27T06:52:37.950691+00:00","id":46676,"links":{},"metadata":{"_buckets":{"deposit":"974e3bad-572c-49d5-875e-bce6321d6bc9"},"_deposit":{"created_by":18,"id":"46676","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"46676"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00046676","sets":["1132:1133:1134"]},"author_link":["342","21335","63343","63344","513","63330","63329","539","81245","333","81251"],"item_59_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"789","bibliographicPageStart":"783","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"Journal of Atherosclerosis and Thrombosis"}]}]},"item_59_creator_5":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"多田, 隼人"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"野原, 淳"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"稲津, 明広"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"馬淵, 宏"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"川尻, 剛照"}],"nameIdentifiers":[{},{},{},{}]}]},"item_59_description_23":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Sitosterolemia is a rare inherited disease characterized by increased levels of plant sterols, such as sitosterol. The cause of this disease is ATP-binding cassette (ABC) subfamily G member 5 or member 8 (ABCG5 or ABCG8, respectively) gene mutations. Recent advances in genetics have revealed that the prevalence of subjects with deleterious mutations in ABCG5 and/or ABCG8 genes could be more than 1 in ~200,000 individuals among the general population. Furthermore, accumulated evidence, including infantile cases exhibiting progression/regression of systemic xanthomas associated with LDL cholesterol levels, have shown that the elevation of LDL cholesterol seems to be the major cause of development of atherosclerosis and not the elevation of sitosterol. Regarding therapies, LDL apheresis, as well as proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, could be useful for sitosterolemia, in addition to ezetimibe and/or colestimide. In this study, we provide the current understanding and future perspectives of sitosterolemia, which is currently considered an extremely rare disorder but is expected to be much more prevalent in clinical settings.","subitem_description_type":"Abstract"}]},"item_59_description_24":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"This article distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.","subitem_description_type":"Other"}]},"item_59_description_7":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院循環器内科","subitem_description_type":"Other"}]},"item_59_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00053008","subitem_identifier_reg_type":"JaLC"}]},"item_59_publisher_19":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本動脈硬化学会 = Japan Atherosclerosis Society"}]},"item_59_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.5551/jat.RV17024","subitem_relation_type_select":"DOI"}}]},"item_59_relation_30":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.jstage.jst.go.jp/browse/jat/-char/ja"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jstage.jst.go.jp/browse/jat/-char/ja","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.j-athero.org/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.j-athero.org/","subitem_relation_type_select":"URI"}}]},"item_59_rights_25":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 日本動脈硬化学会 Japan Atherosclerosis Society"}]},"item_59_source_id_11":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1340-3478","subitem_source_identifier_type":"ISSN"}]},"item_59_source_id_13":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11018976","subitem_source_identifier_type":"NCID"}]},"item_59_version_type_27":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tada, Hayato"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Nohara, Atsushi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Inazu, Akihiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Sakuma, Nagahiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mabuchi, Hiroshi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kawashiri, Masa-aki"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-01-10"}],"displaytype":"detail","filename":"ME-PR-TADA-H-783.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_10","mimetype":"application/pdf","url":{"label":"ME-PR-TADA-H-783.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/46676/files/ME-PR-TADA-H-783.pdf"},"version_id":"2b71fe36-e689-4b72-a6ea-d5e7e67a89e6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Sitosterolemia, Hypercholesterolemia, and Coronary Artery Disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Sitosterolemia, Hypercholesterolemia, and Coronary Artery Disease"}]},"item_type_id":"59","owner":"18","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-01-10"},"publish_date":"2019-01-10","publish_status":"0","recid":"46676","relation_version_is_last":true,"title":["Sitosterolemia, Hypercholesterolemia, and Coronary Artery Disease"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T16:41:43.207561+00:00"}