{"created":"2023-07-27T06:52:39.191621+00:00","id":46708,"links":{},"metadata":{"_buckets":{"deposit":"e3d7c6e4-d77c-44ff-9d38-36b54d0f4605"},"_deposit":{"created_by":18,"id":"46708","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"46708"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00046708","sets":["1132:1133:1135"]},"author_link":["112","81372","68049","81373","81374"],"item_59_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"24","bibliographicPageStart":"18","bibliographicVolumeNumber":"29","bibliographic_titles":[{"bibliographic_title":"Journal of Traditional Medicines"}]}]},"item_59_creator_5":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"御影, 雅幸"}],"nameIdentifiers":[{},{},{}]}]},"item_59_description_23":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Jatyadi Taila(J)はアーユルヴェーダ（インド伝統医学）で用いられる薬用オイルであり，特に薬線Kshara Sutraを用いた痔瘻手術の際に用いられている。この手術方法は日本へも導入されているが，Jについては薬理作用，毒性および術後処置について未だ明らかにされていない。そこで本研究では，培養ヒト表皮角化細胞におけるケモカイン・インターロイキン（IL）-8の産出および細胞増殖作用に対するJの効果を調査した。さらにJの代替品として紫雲膏および中黄膏を構成する生薬に基づいたオイルを調製することを試みた。JはTPAで共刺激された角化細胞中のIL-8 産出に影響を及ぼさなかったが，強い細胞毒性を示した。鬱金で作ったオイルは角化細胞中のIL-8産出および細胞毒性を示した。鬱金および黄柏で作ったオイルはIL-8産出を抑える傾向を示した。Jのメタノール画分は細胞毒性を示さずIL-8産出を抑制した。ゴマ油や紫根で作ったオイルのメタノール画分は有意に角化細胞を増殖させたが，IL-8産出に影響を及ぼさなかった。以上よりJは角化細胞の炎症反応の調節を通じて皮膚炎を抑制する可能性があることが示された。紫雲膏や中黄膏に基づいたオイルがKshara Sutraによる手術を受けた患者に役立つ可能性がある。","subitem_description_type":"Abstract"},{"subitem_description":"An Ayurvedic medicated oil, Jatyadi Taila (J), is known to be used in Ayurveda (Indian traditional medicine), especially for anal fistula surgery involving the medicated thread Kshara Sutra. Although this surgical method has been introduced into Japan, the pharmacological efficacy, toxicity and postoperative care for J remain unclear. In this study, we investigated the effects of this oil on production of the chemokine interleukin (IL)-8 as well as cell proliferation in cultured human epidermal keratinocytes. We also attempted to create an oil for Kshara Sutra based on Kampo ointments such as shiunko and chuoko, instead of J. J itself did not affect IL-8 production in keratinocytes co-stimulated with TPA, but showed a strong cytotoxicity toward this cell line. Among the tested oils, oil of turmeric resulted in suppression of not only IL-8 production but also cell growth in cultured keratinocytes. Oil of turmeric and Phellodendri Cortex showed a tendency to suppress IL-8 production under the same condition. The methanol-eluted fractions of J suppressed IL-8 production without any significant cytotoxicity. The methanol fraction of the oil from sesame or Lithospermi Radix significantly enhanced the proliferation of keratinocytes without IL-8 production. These findings indicate that the Ayurvedic oil J may have potential for suppression of skin inflammation through regulation of the keratinocyte inflammatory response. It is further proposed that Japanese Taila based on shiunko and chuoko might be useful for Kshara Sutra surgery in patients. © 2012, Medical and Pharmaceutical Society for WAKAN-YAKU. All rights reserved.","subitem_description_type":"Abstract"}]},"item_59_description_7":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_59_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00053040","subitem_identifier_reg_type":"JaLC"}]},"item_59_publisher_19":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"和漢医薬学会 = Medical and Pharmaceutical Society for WAKAN-YAKU"}]},"item_59_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.11339/jtm.29.18","subitem_relation_type_select":"DOI"}}]},"item_59_relation_30":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.jstage.jst.go.jp/browse/jtm/-char/ja"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jstage.jst.go.jp/browse/jtm/-char/ja","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.wakan-iyaku.gr.jp/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.wakan-iyaku.gr.jp/","subitem_relation_type_select":"URI"}}]},"item_59_rights_25":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© Medical and Pharmaceutical Society for WAKAN-YAKU"}]},"item_59_source_id_11":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1880-1447","subitem_source_identifier_type":"ISSN"}]},"item_59_source_id_13":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA12035198","subitem_source_identifier_type":"NCID"}]},"item_59_version_type_27":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fukazawa, Ayako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamaguchi, Masaya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takano, Fumihide"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mikage, Masayuki"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-01-10"}],"displaytype":"detail","filename":"PH-PR-MIKAGE-M-18.pdf","filesize":[{"value":"760.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-MIKAGE-M-18.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/46708/files/PH-PR-MIKAGE-M-18.pdf"},"version_id":"c85f30a5-fe70-4490-9f6a-c69f3d298252"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Studies for developing Japanese Taila, an Ayurvedic medicated oil","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Studies for developing Japanese Taila, an Ayurvedic medicated oil"}]},"item_type_id":"59","owner":"18","path":["1135"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-01-10"},"publish_date":"2019-01-10","publish_status":"0","recid":"46708","relation_version_is_last":true,"title":["Studies for developing Japanese Taila, an Ayurvedic medicated oil"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T16:41:29.909825+00:00"}