{"created":"2023-07-27T06:52:39.415067+00:00","id":46713,"links":{},"metadata":{"_buckets":{"deposit":"0d9ef6f8-41cd-452d-86f8-37cfee91fe27"},"_deposit":{"created_by":18,"id":"46713","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"46713"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00046713","sets":["1132:1133:1135"]},"author_link":["81406","81401","81407","81404","81403","81408","81405","44934"],"item_59_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"205","bibliographicPageStart":"199","bibliographicVolumeNumber":"30","bibliographic_titles":[{"bibliographic_title":"Journal of Traditional Medicines"}]}]},"item_59_creator_5":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"嶋田, 努"}],"nameIdentifiers":[{},{}]}]},"item_59_description_23":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Zingiberis Rhizoma の辛味成分である 6-shogaol およびその代謝物 6-paradol の体内動態および薬理活性について， 検討した。 6-shogaol （10 mg/kg） をラットに経口投与した際の血漿中 6-shogaol および 6-paradol 濃度を LC/MS/MSを用いて測定したところ， ともに投与 5 分後で Cmax に到達し， 投与 2 時間後までに速やかに血漿中から消失した。 代謝物である血漿中 6-paradol 濃度はいずれの採血時間においても， 6-shogaol 濃度に比べて約 4 倍高い値を示した。 次に， 6-shogaol および6-paradolの薬理活性について検討したところ， in vitro 実験において 6-paradol は 6-shogaol に比べ約 6 倍強い COX-2 阻害活性を示し， in vivo 実験においても 6-paradol が 6-shogaol より有意に強い抗炎症作用， 鎮痛作用および解熱作用を示した。 このことから， Zingiberis Rhizoma 中の 6-shogaol は体内で速やかに 6-paradol に代謝されること， また代謝物である 6-paradol が抗炎症作用を示すメイン化合物であることが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"This study examined the pharmacokinetics and pharmacological activities of 6-shoganol, a pungent ingredient of Zingiberis Rhizoma, and its metabolite, 6-paradol. The concentrations of 6-shogaol and 6-paradol in rat plasma determined by LC/MS/MS reached their maximum values (Cmax) at 5 minutes after oral administration of 6-shogaol (10 mg/kg). Both 6-shogaol and 6-paradol were eliminated from the plasma within 2 hours after injection. The plasma concentration of 6-paradol, the metabolite, was about 4 times higher than that of 6-shogaol at all points during blood sampling. Next, pharmacological activities of 6-shogaol and 6-paradol were studied. In vitro experiment revealed that the cyclooxygenase-2-inhibitory activity of 6-paradol was about 6 times stronger than that of 6-shogaol. In vivo experiments, 6-paradol demonstrated significantly stronger anti-inflammatory, analgesic, and antipyretic activities compared to 6-shogaol. These results suggest that 6-shogaol in Zingiberis Rhizoma is metabolized rapidly to 6-paradol and that 6-paradol is the main compound having anti-inflammatory activity. © 2013, Medical and Pharmaceutical Society for WAKAN-YAKU. All rights reserved.","subitem_description_type":"Abstract"}]},"item_59_description_7":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_59_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00053045","subitem_identifier_reg_type":"JaLC"}]},"item_59_publisher_19":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"和漢医薬学会 = Medical and Pharmaceutical Society for WAKAN-YAKU"}]},"item_59_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.11339/jtm.30.199","subitem_relation_type_select":"DOI"}}]},"item_59_relation_30":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.jstage.jst.go.jp/browse/jtm/-char/ja"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jstage.jst.go.jp/browse/jtm/-char/ja","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.wakan-iyaku.gr.jp/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.wakan-iyaku.gr.jp/","subitem_relation_type_select":"URI"}}]},"item_59_rights_25":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© Medical and Pharmaceutical Society for WAKAN-YAKU"}]},"item_59_source_id_11":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1880-1447","subitem_source_identifier_type":"ISSN"}]},"item_59_source_id_13":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA12035198","subitem_source_identifier_type":"NCID"}]},"item_59_version_type_27":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tokuhara, Daisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimada, Tsutomu"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Asami, Akitoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Akiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kobayashi, Hiroko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saimaru, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Aburada, Masaki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-01-10"}],"displaytype":"detail","filename":"PH-PR-SHIMADA-T-199.pdf","filesize":[{"value":"628.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-SHIMADA-T-199.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/46713/files/PH-PR-SHIMADA-T-199.pdf"},"version_id":"c17dd0e3-507a-4cb3-9cba-00900bbd9692"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Pharmacokinetics of 6-shogaol, a pungent ingredient of Zingiberis Rhizoma, and the anti-inflammatory activity of its metabolite, 6-paradol","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Pharmacokinetics of 6-shogaol, a pungent ingredient of Zingiberis Rhizoma, and the anti-inflammatory activity of its metabolite, 6-paradol"}]},"item_type_id":"59","owner":"18","path":["1135"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-01-10"},"publish_date":"2019-01-10","publish_status":"0","recid":"46713","relation_version_is_last":true,"title":["Pharmacokinetics of 6-shogaol, a pungent ingredient of Zingiberis Rhizoma, and the anti-inflammatory activity of its metabolite, 6-paradol"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T16:41:36.749563+00:00"}