{"created":"2023-07-27T06:52:44.231009+00:00","id":46834,"links":{},"metadata":{"_buckets":{"deposit":"3d3220c7-4900-4086-81b8-bd05592caa71"},"_deposit":{"created_by":17,"id":"46834","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"46834"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00046834","sets":["1132:1137:3467:3641"]},"author_link":["81617","25678","81616","61511","81619","81618","79189","209"],"item_7_alternative_title_2":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"非荷重でのラット後肢膝関節の不動による関節構成体の変化"}]},"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-02-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"40","bibliographicPageStart":"33","bibliographicVolumeNumber":"42","bibliographic_titles":[{"bibliographic_title":"Journal of wellness and health care "},{"bibliographic_title":"Journal of wellness and health care ","bibliographic_titleLang":"en"}]}]},"item_7_creator_34":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松崎, 太郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"吉田, 信也"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"池田, 亜未"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"細, 正博"}],"nameIdentifiers":[{},{},{},{}]}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The purpose of this study was to establish a method of knee immobilization associated with hindlimb unloading, and to investigate the histopathological changes of the knee joint components after immobilization and unloading.\nForty male Wistar rats were randomly divided into four groups: control group, unweighting group, knee immobilization group, and unweighting + joint immobilization group. The knee immobilization was performed using external fixation. For the hindlimb unweighting, a Kirschner wire was inserted at the rat’s caudal vertebra and a stainless steel wire was attached to the Kirschner wire to allow hindlimb suspension by the tail.\nAfter two weeks of intervention, the body weight and knee range of motion were measured, and the histopathological changes in the articular cavity and joint capsule were examined. There was no significant difference between the body weight and the range of joint motion among the 4 groups before the intervention. After the experimental period, the average body weight was no statistically significant between them.\nThe knee range of joint motion was no significant different between unweighting group and control group, however, immobilized groups had significant decrease in comparison with non-immobilized groups. In unweighting groups, the cartilage was directly exposed to the articular cavity, and the surface of the articular cartilage was smooth. Conversely, invasion and adhesion of the granulation-like tissue into the joint cavity were observed in joint immobilization groups. Joint capsule of control groups and unweighting groups was typically composed of coarse and relatively loose fibrous connective tissues. The immobilized groups presented dense collagen bundles with narrow interstitial spaces and congested blood vessels in all cases. In the knee immobilization associated with unweighting group, the increase in collagen fiber density was less obvious in comparison with that observed in animals of immobilized group.\nAlthough the Kirschner wire insertion is an invasive intervention, the animals in our study showed increasing body weight compared to the baseline weight. In addition, no suspension failing episodes were observed across the study, thus there was no need to re-suspend or drop-out animals. Therefore, the tail suspension technique using Kirschner wire reported in this study, could be safer and a less stressful technique of hindlimb suspension compared to other conventional techniques.\nWe also concluded the method described in this study does not allow weight bearing during joint immobilization resulting in better simulation of the joint contracture observation in clinical practice.","subitem_description_type":"Abstract"},{"subitem_description":"今回の実験の目的は、ラット後肢を非荷重としたまま飼育する方法を確立すること、および荷重の有無が関節不動による関節構成体の変化にどのように影響するのかを調査することである。\n　40 匹の Wistar 系雄性ラットを使用し、無作為に 4 群に分けた。それぞれ対照群、非荷重群、関節不動群、不動と非荷重群とした。関節不動は創外固定を用いて後肢膝関節を屈曲 120 度で不動化した。非荷重群はラットの尾骨に Kirschner 鋼線を刺し、ステンレスワイヤを用いて尾部を懸垂し、足部が接地しないようにした。\n　介入の 2 週後、体重と関節可動域を測定した後に関節腔と関節後方の関節包を病理組織学的に観察した。\n　実験後の体重には各群に差は見られなかった。関節可動域は対照群および非荷重群に対し不動群、関節不動と非荷重群で有意に減少していた。また、不動と非荷重群と比較して関節不動群では有意な可動域の減少が見られた。関節腔では対照群、懸垂群は軟骨が直接関節腔に露出していたが、関節不動群、不動と非荷重群では肉芽様組織の関節腔内の侵入，関節軟骨表層の膜様組織との癒着が観察され，不動と非荷重群では軟骨表層の膜様組織は限局的であった。関節包は対照群、非荷重群ではコラーゲン線維間に間隙を認め，比較的疎性であったが，関節不動群ではコラーゲン線維束はやや組硬化し，線維素区間が狭まり密生化しており，全例でうっ血像が観察された。不動と非荷重群では線維の密生化は見られたものの関節不動群と比較して軽度であった。\n　今回の手技は侵襲はあるものの懸垂が外れることはなく、より臨床での関節拘縮に近い研究を行う一助となると考えられる。","subitem_description_type":"Abstract"}]},"item_7_heading_33":{"attribute_name":"見出し","attribute_value_mlt":[{"subitem_heading_banner_headline":"原著","subitem_heading_language":"ja"},{"subitem_heading_banner_headline":"Original Article","subitem_heading_language":"en"}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00053162","subitem_identifier_reg_type":"JaLC"}]},"item_7_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"ウェルネス・ヘルスケア学会 "}]},"item_7_publisher_19":{"attribute_name":"出版者（別名）","attribute_value_mlt":[{"subitem_publisher":"Wellness and Health Care Society "}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2434-1509","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsuzaki, Taro"}],"nameIdentifiers":[{"nameIdentifier":"25678","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshida, Shinya"}],"nameIdentifiers":[{"nameIdentifier":"81616","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikeda, Ami"}],"nameIdentifiers":[{"nameIdentifier":"81617","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hoso, Masahiro"}],"nameIdentifiers":[{"nameIdentifier":"79189","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-02-01"}],"displaytype":"detail","filename":"24341509-42-2-33-40.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"24341509-42-2-33-40","url":"https://kanazawa-u.repo.nii.ac.jp/record/46834/files/24341509-42-2-33-40.pdf"},"version_id":"f5f7d428-e881-40d9-b76c-9969c7e8bef9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Joint immobilization","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hindlimb Unweighting","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tail suspension","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Changes in joint components after knee immobilization associated with hindlimb unweighting in rats.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Changes in joint components after knee immobilization associated with hindlimb unweighting in rats."}]},"item_type_id":"7","owner":"17","path":["3641"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-02-01"},"publish_date":"2019-02-01","publish_status":"0","recid":"46834","relation_version_is_last":true,"title":["Changes in joint components after knee immobilization associated with hindlimb unweighting in rats."],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-07-27T16:25:11.353682+00:00"}