{"created":"2023-07-27T06:52:45.321215+00:00","id":46861,"links":{},"metadata":{"_buckets":{"deposit":"7125b72d-4c44-4b7f-8c3a-0f77ec5439a4"},"_deposit":{"created_by":18,"id":"46861","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"46861"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00046861","sets":["2229:2230:2231"]},"author_link":["224","81231"],"item_59_biblio_info_10":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"38","bibliographicPageStart":"35","bibliographicVolumeNumber":"22","bibliographic_titles":[{"bibliographic_title":"日本生物学的精神医学会誌"},{"bibliographic_title":"Japanese journal of biological psychiatry","bibliographic_titleLang":"en"}]}]},"item_59_creator_5":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Munesue, Toshio"}],"nameIdentifiers":[{"nameIdentifier":"81231","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50293353","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50293353"}]}]},"item_59_description_23":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Oxytocin is a neuropeptide that is released into the general circulation from the nerve endings of the posterior pituitary and into the brain from dendrites. The half-life of oxytocin in the brain is longer than that in the blood (about 20 min vs. 2 min, respectively) . Oxytocin is involved in social recognition, pair bonding, and maternal behavior. The transmembrane glycoprotein CD38 regulates oxytocin release, and CD38-knockout mice show insufficient oxytocin release. We have found a single nucleotide polymorphism (SNP) in the exon region of the CD38 gene in a subpopulation of individuals with autism spectrum disorder (ASD) . Oxytocin signaling, including CD38 and oxytocin receptor, is suggested to play an important role in the pathophysiology of ASD, although we did not demonstrate an association between the CD38 gene SNP and ASD. Oxytocin administered using a nasal spray penetrates directly into the brain and not via the general circulation. Four studies have suggested the effectiveness of a single shot of oxytocin in the treatment of ASD. We observed marked improvement in severe irritability shown by two ASD patients using oxytocin nasal spray. The effectiveness of oxytocin in the long-term treatment of patients with ASD should be rigorously investigated in a randomized controlled crossover trial.","subitem_description_type":"Abstract"},{"subitem_description":"Oxytocin は下垂体後葉から血中に分泌されるだけでなく，主に樹状突起から脳内にも分泌される。この際に CD38 が重要な役割を担っており，CD38 knockout マウスでは oxytocin の十分な分泌がなされない。CD38 の DNA 解析により，exon 部分のある single nucleotide polymorphism（SNP）を有する自閉症スペクトラム障害（autism spectrum disorder ： ASD）者の血中 oxytocin 濃度は SNPを有さない ASD 者に比べ有意に低かったが，この SNP と ASD との関連性を十分に示すことはできなかった。鼻腔投与された oxytocin は血液循環を経ずに直接に脳内に移行すると考えられる。また脳内では半減期が長く，広く拡散することが可能であり，かつ受容体に結合するとその神経細胞は oxy-tocin をさらに分泌する。Oxytocin が ASD の症状の一部を改善する臨床研究がいくつかある。 Oxytocin nasal spray による ASD 者を対象とした長期間の臨床試験が望まれる。","subitem_description_type":"Abstract"}]},"item_59_description_7":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学子どものこころの発達研究センター","subitem_description_type":"Other"}]},"item_59_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00053188","subitem_identifier_reg_type":"JaLC"}]},"item_59_publisher_19":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本生物学的精神医学会 = Japanese Society of Biological Psychiatry"}]},"item_59_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.11249/jsbpjjpp.22.1_35","subitem_relation_type_select":"DOI"}}]},"item_59_relation_30":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.jstage.jst.go.jp/browse/jsbpjjpp/-char/ja"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jstage.jst.go.jp/browse/jsbpjjpp/-char/ja","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.jsbp.org/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.jsbp.org/","subitem_relation_type_select":"URI"}}]},"item_59_rights_25":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 日本生物学的精神医学会 Japanese Society of Biological Psychiatry"}]},"item_59_source_id_11":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2186-6619","subitem_source_identifier_type":"ISSN"}]},"item_59_source_id_13":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA12468060","subitem_source_identifier_type":"NCID"}]},"item_59_version_type_27":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"棟居, 俊夫"}],"nameIdentifiers":[{"nameIdentifier":"224","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50293353","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000050293353"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-02-14"}],"displaytype":"detail","filename":"CH-PR-MUNESUE-T-35.pdf","filesize":[{"value":"227.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CH-PR-MUNESUE-T-35.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/46861/files/CH-PR-MUNESUE-T-35.pdf"},"version_id":"ffe74348-a135-4357-938d-51eb7eee1529"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"自閉症スペクトラム障害における oxytocin の有効性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"自閉症スペクトラム障害における oxytocin の有効性"},{"subitem_title":"Effectiveness of oxytocin in subjects with autism spectrum disorder","subitem_title_language":"en"}]},"item_type_id":"59","owner":"18","path":["2231"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-02-14"},"publish_date":"2019-02-14","publish_status":"0","recid":"46861","relation_version_is_last":true,"title":["自閉症スペクトラム障害における oxytocin の有効性"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-06-27T01:14:30.873702+00:00"}